Chapter 1044 A Super Gold Mine

Yang Ping's tumor treatment project is in progress. His current goal is to use a certain virus combined with K factor to create an oncolytic virus. This method belongs to oncolytic virus therapy, which is referred to as OVT in medicine.

The current mechanism of oncolytic virus treatment is to stimulate the immune system to attack virus-infected tumor cells, increase the number of tumor B cells, T cells, macrophages and other immune cells, so that these immune cells can fight and attack tumor cells.

But Yang Ping's idea is not like this. His virus is just a delivery vehicle. It is K factor that attacks tumor cells, and the mechanism is the principle of apoptosis.

Therefore, strictly speaking, it should have a brand new name and not be called oncolytic virus therapy.

It should be called virus-carrying K factor tolerance-free targeted therapy, or tumor virus therapy.

Beata Halasi, who successfully used oncolytic virus therapy to treat triple-negative breast cancer, used measles virus and vesicular stomatitis virus. These viruses can infect the type of cells from which breast cancer originates, and have been used in the treatment of triple-negative breast cancer before. used in clinical trials.

The experience of his predecessors has strengthened Yang Ping's confidence. At least he can choose many more viruses than his predecessors, because many viruses have been tested by his predecessors. Even if some of them are not effective, they are at least harmless to the human body. , or the side effects can be controlled within an acceptable range.

For example, measles virus strains are widely used in childhood measles vaccines, and vesicular stomatitis viruses can only induce mild flu symptoms in the worst case, so they are very safe in humans.

Security is the most basic condition for using viruses as delivery vehicles.

When Beata Harassi uses these two viruses, she does not use them as delivery vehicles, but lets them infect tumor cells and directly activate the body's immune system to attack the viruses, because at this time the viruses and tumor cells are combined. Together, these immune cells attack tumor cells as well as viruses.

But Yang Ping now regards the virus as just a delivery vehicle, leaving the task of killing tumor cells to K-factor, just like a missile carrying a nuclear warhead. The missile is just a delivery vehicle, while the nuclear warhead is the weapon that exerts the ultimate destructive effect.

Although this method also uses viruses to deal with tumors, it is completely different from oncolytic virus therapy. It is a brand-new tumor treatment method.

When choosing this virus, you need to consider that the virus can infect the original cells of the tumor. For example, Sisi's primary tumor is osteosarcoma, and the source cells of osteosarcoma are osteoblasts. Therefore, the virus that treats this tumor must be able to infect adult cells. bone cells.

In oncolytic virus therapy, one method is to inject the virus directly into the tumor to stimulate an increase in the number of immune cells and use the immune cells to attack the tumor. This was the method used by Beata Halasi when she herself was suffering from the disease. Triple-negative breast cancer recurred after traditional surgery and chemotherapy. There was no need for another surgery after the recurrence. Her body could no longer withstand chemotherapy. She herself is a virology expert, so she cultivated the virus to treat herself and achieved good results. and publish papers in reputable medical journals.

Of course, at that time, her paper was rejected by more than a dozen journals due to ethical issues, because it was ethically controversial to conduct experiments on herself.

Yang Ping sorted out his topic again. The ideas in his mind became clearer and his confidence became stronger. The top priority was to screen out the suitable virus and then complete the transformation of the virus so that it can carry the K factor. To complete this step, In theory, this is only half the battle.

Several major laboratories are located upstairs in the ward of the Institute of Surgery, which makes Yang Ping's communication with the scientific researchers in the laboratory very smooth. He can go to the laboratory at any time to take a look and walk around to learn about the latest experiments. state.

Yang Ping looked at the time. It was still early. The first few surgeries today were performed by Song Zimo, Xu Zhiliang and Xia Shu. He just took the time to go to the laboratory to ask about the current progress.

The building where the Institute of Surgery is located has eight floors, which is enough for now, and the space is relatively ample. The stem cell laboratory and tumor laboratory occupy a separate floor, and the hardware conditions in all aspects are world-class.

Scientific research is nothing more than three elements: talents, equipment and environment. This environment is mainly a humanistic environment. The humanistic environment for scientific research must have a scientific and engineering temperament, simple, relaxed, free and equal.

If the scientific researchers in the laboratory have to flirt with each other, engage in a drinking culture, and form cliques every day, then even the best hardware in the universe will not be enough.

People who are serious about scientific research have no interest or disdain to study wine culture. They just want to make a name for themselves in this one-third of an acre of land.

Therefore, Yang Ping attaches great importance to the cultural construction of the laboratory. The establishment of cultural traditions is particularly important for the future survival and development of the laboratory. When he went to the laboratory, everyone had already started working and everyone was starting their own work.

These people did not put aside their work to come and watch or line up to welcome Yang Ping. Not only did Yang Ping not feel that he was left out, but he was pleased that the culture of the laboratory was taking shape.

"How is the virus screening work going?" Yang Ping was sitting in Lu Xiaolu's office.

Lu Xiaolu stood up and walked to a whiteboard. There were many small cards hanging on it. Each small card had a picture of a virus. There were more than a dozen such cards hanging on the whiteboard.

"Currently, this is what is left after our screening. With a little more time, we can find a few suitable viruses and start modifying them. We have already come up with several phage modification plans, but the manual modification efficiency is too low. Our entire It is estimated that the team can only come up with dozens of solutions a year. Professor He is working on a model. They said they would first produce a simple model for us to use. We will wait until the artificial intelligence model comes out before using the large artificial intelligence model. Professor He said that using his temporary small model, we can successfully come up with tens of thousands of solutions in one hour. If we use his large model in the future, we can successfully produce tens of thousands of solutions in one second. These virus models can be run through hundreds of thousands or millions of dollars in his virtual model to optimize and eliminate them," Lu Xiaolu replied.

Yang Ping nodded. Today's scientific research is no longer the same as it was a hundred or two hundred years ago. The era of relying on simple experimental conditions to achieve results is gone forever. Today's scientific research must rely on advanced tools, and the application of artificial intelligence in scientific research can Save a lot of time and relieve scientific researchers from heavy work.

"I think so too. In the future, we need to introduce artificial intelligence into scientific research, and try to use artificial intelligence to replace repetitive, boring, and non-imaginative work, so that everyone can focus their time on high-value work."

"You have gotten used to working here recently. If you need anything, tell me. Is Principal Ding okay?" Yang Ping asked with concern.

Speaking of Principal Ding, Lu Xiaolu's expression became solemn: "I visited him last week, and now I go to see him every month and send him some things. His mentality inside is now very good, just don't worry. No less than Ding Xinyu.”

Poor parents in the world, even though he is in prison, Principal Ding still misses his daughter.

"Ding Xinyu is in good condition now. She works as a teacher in a vocational and technical school. The school attaches great importance to her. I also go to see her and the child every weekend. The child is still young and has suffered great psychological trauma. Teacher Ding has always warned her I have to take good care of Yu Xin, this is what he cares about most.”

"There has been no news about Guan Ruyan. He was seen wandering in Los Angeles, USA, but the authenticity of this matter cannot be confirmed. He must have brought it upon himself. Throughout his life, he has always used others, and everyone is his tool. He abandoned one person after another who loved him deeply, and now he also experiences the feeling of being abandoned by others. "

Talking about this, Lu Xiaolu was inevitably a little sad. After all, he and Guan Ruyan had studied and worked together for so many years, and they had some feelings for each other. It would be unrealistic for them to be stolen from their hearts all at once.

Lu Xiaolu was introverted and had no friends since he was a child. If he could be considered friends, they were only Guan Ruyan and Ding Xinyu. After all, they had studied together at Nandu Medical University and then studied in Germany together. Their student days at that time were still very busy. Beautiful, some things can only be missed and can never be taken back.

"I plan to marry Ding Xinyu." Lu Xiaolu said suddenly.

This made Yang Ping a little surprised. Lu Xiaolu said: "I don't have many friends, so I can only chat with you. Ding Xinyu is a joke in everyone's minds now. In everyone's eyes, she is stupid and self-inflicted, but to me In my eyes, she is Teacher Ding’s daughter, my junior sister, and the woman who needs the most care. I don’t care what others think, I will marry her. As long as she agrees, I don’t know if this will affect our laboratory. reputation."

It turned out that Lu Xiaolu was worried about this, and Yang Ping said on the spot: "This is your private matter and has nothing to do with work, so you can do whatever you want. As for what others think of you, you just have to be able to bear it."

Lu Xiaolu breathed a sigh of relief: "I understand. She needs love and protection most now, and the child also needs a complete family. Teacher Ding only has a few days to live, and I hope he can leave peacefully."

''You can do whatever you want, as long as it doesn't break the law, doesn't violate your conscience, and doesn't affect others. "

Lu Xiaolu smiled and said: "Actually, I think so too. I don't care about those gossips. I just want to be myself."

"Look, talking to you about these irrelevant things during working hours takes up your time." Lu Xiaolu took back the topic he had strayed from.

Yang Ping smiled and said: "I came here to chat with you. We can chat wherever we go. There is no rule that we must talk about work."

"We can benefit a lot from working with Brian. He is now the world's top in immunology research, and he said that he will introduce a professor of virology to cooperate with us, so that I can make up for all the shortcomings at present. plate."

Lu Xiaolu admires Yang Ping's open academic spirit very much. Yang Ping is now among the best in the world, but he has never rested on his laurels. He still actively seeks exchanges and cooperation and carries out extensive exchanges and cooperation on the basis of independence. Neither resting on one's own laurels nor blindly following others, always learning from each other's strengths and making up for one's shortcomings, and always standing at the top level of world academics. This is the true rational academic spirit.

The world's science and technology develops so fast and covers such a wide range. Many fields require decades or even hundreds of years of accumulation. If any technology has to be studied from beginning to end by oneself, it may be difficult to keep up with the top level. Therefore, learning is so important at this time. Learning from others through communication and cooperation and standing on the shoulders of others can avoid unnecessary waste.

After leaving the oncology laboratory, Yang Ping came to the stem cell laboratory. The stem cell laboratory can currently successfully cultivate complete muscle tendon units. These muscle tendons have been used in limited clinical applications, such as muscle transplantation for trauma patients with muscle loss. Grafting, providing grafting materials for patients undergoing anterior and posterior cruciate ligament reconstruction of the knee.

Skin amplification technology has now begun to be promoted, providing an almost inexhaustible source of high-quality skin for burn departments that require large-area skin grafting operations. Even if there is a piece of normal skin on the body, it can be used through the amplification technology , to obtain skin materials that can cover the whole body.

The stem cell laboratory is intensively carrying out stem cell injection treatment and using stem cells for anti-aging treatment. Some qualification licenses are being applied for. Currently, Sanbo Hospital is a hospital directly managed by the Imperial Capital. The application for these licenses is very easy and cannot be compared with ordinary hospitals.

Time management master Tang Shun used to always have a mobile phone on his desk, with his fingers flying and WeChat avatars switching one after another at high speed. The top Neptune must be a person with special skills.

In the words of Fatty Liang, Tang Shun is the world's top sea king. Regardless of the variety, quality or geographical distribution of the fish he raises, he is well-deserved to be the top.

But today, Tang Shun didn't have a mobile phone on his desk, and his fingers weren't flying at high speed. He was sitting quietly behind the desk, holding a stack of information in his hand, checking some data.

Seeing Yang Ping come in, he immediately stopped what he was doing: "Professor!"

"I'll come over and have a chat with you."

"Look, Professor? This is the latest status of our anti-aging project. We haven't started it directly yet. Now many laboratories and companies around the world that rely on this to make money are hoping to pre-order our goods. I just took a look. Prepaid They can collect more than 4 billion US dollars in fees. These people are really rich. We are completely relying on a mountain of gold. This is because we have just released the news that our surgical institute now has a strong reputation in the world of medicine."

It turns out that Tang Shun is settling accounts. What can this guy say about him? He is such a good guy. He is an all-rounder with high professional level and organizational skills. Most importantly, he can make money. Since he managed the laboratory, the laboratory has been like a building. There is an endless gold mine, and every once in a while he can do some flower work to make money, and the money is earned openly and without any faults.

"Look, these are American technology tycoons, these are Russian oligarchs, and these are old British financial giants. These people are all inquiring about the situation of our stem cell laboratory. As long as these people can extend their lives, money will come to them. "It's not even a figure. I haven't received any formal consultation from them yet. Once this door is opened, money will flow out like water from the Three Gorges Dam."

"However, Professor, our security measures must be upgraded. Each of these ghosts is better than the last. I started as a pirate, and robbery is engraved in my bones. Many spies will definitely be sent to infiltrate our place. Who doesn't want to control this place?" It’s the golden mountain of medicine.”

Tang Shun was a little excited that the new project was so popular, but this was also expected.

"The computers in our laboratory are being replaced from system to various software, and we are striving to gradually realize all domestic control. These basic things are usually not considered important at critical times. We cannot leave the vitality in the hands of others. I I’ve already talked to Mr. Huang and it’s up to them to complete these matters.”

Tang Shun shook a list in his hand and handed it to Yang Ping to read.