Chapter 1051: The Whole Army Is Annihilated

Sisi's high fever continued to persist, and Yang Ping could only temporarily use ice caps and ice blankets for physical cooling. By the next morning, Sisi still had no signs of fever.

In order to keep the airway open, the nurse had intubated Sisi, and life support such as ventilators and ECMO were prepared nearby, which could be used at any time when needed.

Yang Ping observed the changes in Sisi's condition while thinking about countermeasures. There is no precedent to refer to for what kind of reaction this virus will cause to the human body.

The impact of the source virus on the human body has no reference value, because after the K factor is implanted, the symptoms caused by the new virus are completely absent from the source virus. The source virus can only cause mild flu symptoms, and the current K virus actually causes a continuous high fever of 42 degrees Celsius.

Yang Ping's thinking is now very clear, using physical cooling to reduce body temperature as much as possible, reduce brain tissue metabolism, and protect brain tissue and other important organs from damage. Maintain Sisi's fluid balance and electrolyte balance, and maintain her normal nutrition and energy supply. As for fever reduction, leave it to the body's own immunity.

These viruses have been castrated for replication, so as long as Sisi can survive the virus's own survival time, then after the viruses die naturally one after another, the number of viruses will gradually decrease, and the high fever will naturally subside.

This is actually similar to the treatment ideas of most diseases. Symptomatic treatment relieves symptoms and ensures the safety of life, and causal treatment is left to the body's own immunity.

Yang Ping and Song Zimo stayed up all night. When Xu Zhiliang, Xia Shu, and Dr. Jin came to work in the morning, they asked to switch shifts with them. Now is the high fever period, Yang Ping dare not relax. He asked Dr. Jin to stay by the bed, and Xu Zhiliang and Xia Shu went to the department to handle work. He and Song Zimo took turns sleeping and resting on the bed of the accompanying person in the ward. After all, we don't know how the disease will develop later. If we can sleep for a while, we should try to maintain sufficient physical strength to cope with future changes in the disease.

There are also three nurses, several doctors and masters participating in Sisi's experiment. Yang Ping asked them to change shifts, and new personnel took over their work and let them go back to rest.

Sisi's parents were allowed to come in for a short visit, but they were not allowed to stay in the ward for long. After all, this kind of intensive care and treatment is not a joke, and any extra personnel will interfere with medical activities.

Seeing their daughter lying unconscious on the bed, the couple just burst into tears and felt extremely painful, but they could not say it out loud, and they could not interfere with Professor Yang's normal treatment. After just a few minutes of visiting, Sisi's father pulled her mother and said, "Let's go, let's go out."

The heart rate on the ECG monitor next to the bed is constantly rising, which is much higher than normal. For every degree Celsius increase in body temperature, the heart rate will increase by 12-18 times. Now Sisi's heart rate is already 150 times. If this high heart rate is maintained for too long, the heart will fail.

This is the same as the engine of a car. If the maximum speed is maintained for a long time, it is easy to explode. The same is true for the heart. If the heart rate is maintained at a much higher than normal heart rate for a long time, it is easy to cause arrhythmia, heart failure, and cardiac arrest.

Yang Ping and Song Zimo were sleeping and resting on the bed next to them. Dr. Jin, who was on duty, saw that the heart rate had been rising slowly and was now likely to exceed 160 beats/minute. He was not sure whether it needed to be treated, but he did not dare to make a decision on his own, so he had to wake up Yang Ping who was resting.

After Yang Ping woke up, he looked at the numbers on the monitor, then listened to Sisi's heart with a stethoscope, and stared at the ECG waveform on the monitor without any expression.

"What should I do? Should I use drugs to lower the heart rate?" Dr. Jin was worried beside him, and Song Zimo also stood up and stood beside him.

In fact, when facing such a life-and-death challenge of the patient, the ability of the attending doctor is extremely tested. He needs to combine his knowledge, experience and the patient's clinical manifestations to make an accurate judgment, which is related to the patient's life and death.

Yang Ping observed the electrocardiogram for a full five minutes without saying anything. Dr. Jin and Song Zimo were also worried. The heart rate on the monitor was now fluctuating around 160 beats/minute, and they could not guarantee whether it would continue to rise.

In this case, the heart can collapse at any time, so it is very difficult to make a choice at this time.

Yang Ping finally spoke, and he shook his head: "No! Keep observing! If the heart rate is lowered, the drugs that lower the heart rate will inhibit myocardial contractility and lower blood pressure. Once used, the heart rate will be lowered, but the brain will be insufficiently supplied with blood due to perfusion fatigue, which can easily cause irreversible damage to brain tissue. This is likely to result in a result: the heart has not collapsed yet, but a large area of ​​brain tissue has died."

Dr. Jin and Song Zimo thought about it, and it was indeed the truth. Yang Ping considered it more thoroughly and deeply.

"What should we do now?" Dr. Jin couldn't help asking.

"Now we can only let her bear it herself, let her own immunity deal with it all. We can only deal with and rescue sudden dangers and provide life support. We can't help with other things. Everyone must stay calm and rational. A mistake in handling a detail will cause irreversible consequences."

At this time, Sisi twitched from time to time, and Yang Ping told the nurse to strengthen respiratory care to prevent suffocation during twitching. Anyway, we should focus on the heart and lungs, two vital organs, and deal with any abnormalities immediately.

This independent ward is equipped with a variety of high-end rescue equipment. It was originally intended to be used as an independent ICU for the Surgical Research Institute. The decoration and equipment have been completed, but the staff has not yet arrived, so it is temporarily vacant. Now it is just right to be used as a laboratory ward for Sisi, so as not to put Sisi in the ICU and add huge pressure on the doctors and nurses in the ICU.

"Is it okay to twitch like this?" Dr. Jin asked again. After all, Dr. Jin has been an orthopedic surgeon for so many years and has little experience with high fever convulsions in children. He is a little worried.

Yang Ping said with confidence: "Don't worry, leave the equipment here, let her twitch. Now strengthen the monitoring of the heart and lungs, pay attention to fluid replenishment and energy replenishment, and we will help her get through it."

After that, Yang Ping lay down on the accompanying bed to sleep. Dr. Jin is very alert and down-to-earth, and Yang Ping is still very confident in him. If it were other young doctors, Yang Ping would definitely not be confident. Inexperience can easily lead to misjudgment, and there is a lack of sufficient identification and early warning capabilities for some potential risks.

Around 4 p.m., Sisi's temperature began to drop, indicating that the virus began to die in the body one after another. The tug-of-war between the immune system and the virus began to tilt towards the immune system, and the virus began to lose.

This is good news. Not only is Sisi likely to survive, but there is also a very important point. Although the virus and the source virus have a great difference in their effects on the human body, they are probably no longer the same type of virus. In other words, the addition of the K factor has completely changed the nature of the virus.

Now it can be preliminarily estimated that the K virus is a brand new virus for the human body. The human body cannot produce antibodies to it, and can only rely on excessive and extensive immune ability to fight it. The risk of this confrontation is extremely high. If it fails, the human body will collapse. Fortunately, these viruses have lost the ability to replicate, and one less dies, so their combat effectiveness is extremely limited.

From the injection of the K virus to the present, when the body temperature has shown a downward trend, the nurse has drawn a lot of Sisi's blood samples, which will be used for various tests to dynamically monitor the changes in various indicators of the human body under the action of the virus.

In fact, some of the detection reagents for these blood samples are also brand new and were specially made for this laboratory. Because the existing test reagents cannot detect many new indicators, such as the markers of these viruses.

It is not known whether some viruses can be found in the blood samples for research, especially to study whether the virus has mutated in the body, because these viruses have no replication ability, so the mutation will not be inherited and it is difficult to capture.

After the body temperature dropped, Sisi sweated a lot, and the whole bed sheet was stained with sweat. The nurse changed the bed sheet, changed Sisi into dry clothes, and increased the amount of fluid to maintain the balance of fluid.

On the ECG monitor, the heart rate also slowly dropped with the drop in body temperature, and Yang Ping was temporarily relieved.

——

Nandu Medical University, the Virology Laboratory and the Digital Medicine Laboratory are working intensively. They received the data of this experiment and immediately began to revise the K virus and the experiment.

At the beginning, the intelligent model of the digital medical laboratory conducted virtual deductions for hundreds of thousands of times. The probability of such high fever was extremely low, less than one in 100,000. Such a low probability actually happened to Sisi. Either she was unlucky and encountered this one in 100,000 probability, or the model prediction was wrong. The actual probability of such a high-risk result was much higher than the model prediction.

Of course, science cannot be left to luck, so Professor He and his team tacitly assumed that the reason was the latter, and they began to check and improve the model.

The data of this experiment is very valuable. It is not an animal experiment, but direct clinical experimental data, which has great value for model correction.

Professor He's team improved their own model, and Professor Zhang Zhiwei was not idle either. They began to further analyze the structure of the virus. Where should the K factor be implanted? What kind of changes need to be made to the genes of the source virus? These are all issues that should be reflected on.

They must re-analyze and summarize the structure of the virus, and it is best to refer to the experimental data of this experiment to re-correct the implantation of each part in theory.

Professor Zhang's team also had to look for the K virus in the blood samples sent over. Although this task was very difficult and it was difficult to find the virus in the blood now, they wanted to try it because as long as they could find the virus, they could observe whether the virus mutated after entering the human body, whether there were any changes, and whether the implanted K factor was still working.

——

Sisi was still in a state of confusion, but her vital signs were stable, which gave Yang Ping great confidence.

He began to puncture Sisi's liver and lung tumors, and punctured them accurately under the monitoring of the navigation instrument, so that some tumor cells could be taken out. Then these tumor cells were taken to the laboratory for analysis under the electron microscope.

This can confirm whether the K virus has successfully infected the tumor cells, and if it has successfully infected the tumor cells, whether they have successfully started the apoptosis program of the tumor cells, and if they have started the apoptosis program, what is the process like.

This analysis must target tumor cells, there is no other way.

Yang Ping knew that Sisi had just escaped death, and it was still uncertain whether she could escape. At this time, various punctures would undoubtedly aggravate her injuries. However, if he did not seize this opportunity to puncture, once the opportunity was missed, even if the virus infected the tumor cells, he would not be able to obtain the true state of these tumor cells in the early, middle and late stages after infection.

To save her, he could not be soft-hearted at this time, and he must follow the principle of rationality in everything.

As long as the metastatic tumors could be punctured, Yang Ping punctured all of them, and took a lot of specimens to the electron microscope laboratory of Nandu Medical University, where he would observe them personally.

Under the electron microscope, Yang Ping searched for specimens one by one, which required great patience, because the virus was hit by the human immune system during transportation, and it was unknown how many tumor cells it could successfully infect.

So some of the specimens taken now may be normal cells, and some are tumor cells, but they may not be infected, because the infected cells may not have been taken at all.

Yang Ping could only look for specimens one by one in person. This work could not be replaced by software models or artificial intelligence, because no matter whether it was software models or artificial intelligence, they must be based on the data of doctors. These new experiments did not have any historical data to feed such models, and these models were useless.

After looking for hundreds of shots of pictures, Yang Ping finally found an abnormal tumor cell. He immediately took out the picture of this cell for research. He found that this cell was a cell infected by the virus because it still had the protein structure of the K virus.

But unfortunately, this cell did not show apoptosis, that is, the K virus did not start its apoptosis program. Whether it did not enter the start-up program or could not start at all, it is now unknown.

Only by continuing to search can we explain the problem. If all cells did not enter the apoptosis program, then these viruses may not have started the apoptosis program of tumor cells.

If these tumor cells are in different states, even if only one cell enters the apoptosis program, it means that the K virus can infect tumor cells and start its apoptosis program.

Yang Ping decided to continue searching, and Song Zimo brought several doctors and masters to help Yang Ping search.

Yang Ping taught them the knowledge of reading electron microscope images and asked them to relax the indications, but they should bring any suspicious samples to Yang Ping for review, so as to reduce the number of missed specimens.