Chapter 1050 High Fever

In the virus laboratory of Nandu Medical University, the K virus has been cultivated, and the follow-up work is being carried out in an intense and orderly manner. For this experiment, the researchers worked overtime to catch up with the time. They cherish this cooperation with Professor Yang Ping, because Yang Ping has long been a god-like figure in everyone's mind.

At this time, the researchers' faces were filled with joy and excitement, but their movements were extremely cautious. They knew that this time was different from the past. Although the source virus was a safe virus that was harmless to humans and animals, this time the virus would be directly used in human experiments, and the safety of the experimental subjects might be endangered if they were not careful. Therefore, they always maintained a high degree of vigilance and concentration to ensure that every step was accurate and to avoid mistakes as much as possible.

The K virus samples will undergo a series of tests. During the test process, the researchers need to constantly observe and record the data and analyze the test results. Their eyes are firm and focused, and every slight change in the data touches their heartstrings.

After standardized testing, the K virus meets the laboratory conditions, and everyone is relieved. Everyone knows that Professor Yang has a time-sensitive requirement for this experiment, so everyone tries to cooperate as much as possible, hoping not to delay Professor Yang's experiment.

The qualified viruses will enter the packaging process, which is extremely strict. They will seal a certain amount of viruses into special biological preparation bottles in a sterile environment, make bottles one by one, and then label them and store them in the refrigerator. Just like vaccines, their storage and transportation processes are traceable cold chains.

When these K virus biological preparations that can be used for clinical trials at any time were produced, the atmosphere in the laboratory reached a climax, and the researchers cheered and celebrated each other.

Regardless of whether this clinical trial is successful or not, they have taken a new step with Yang Ping. They will be the first in the world to combine the protein factor that can start the tumor cell apoptosis program with the carrier virus, artificially creating a new virus, the first virus in the world that can kill tumors, and this virus has also opened up a separate category in classification. Regardless of success or failure, their current work is to uncover a new field. As participants, they are of course very excited.

Professor Zhang Zhiwei put these preparations into the portable refrigerator for storage through the goggles of the protective suit. In the past few days, Professor Zhang has been thinking about Yang Ping's aggressive and time-consuming laboratory method. In fact, it is not all disadvantages. If other factors are not considered, objectively speaking, this method also has certain advantages.

According to the conventional procedure, the computer simulation experiment is first, followed by animal experiments, and then phase I, II and III clinical trials, and finally clinical application. Now Yang Ping directly applies the virus to patients. In fact, he is not simply blindly taking risks, but has made a very comprehensive assessment of the virus, and the probability of risk events is very small. The current condition of the patients receiving treatment is very urgent and there is no time to wait. This is her only possible effective method.

Combining the two aspects, from the perspective of risk and benefit, Yang Ping's choice is undoubtedly very smart. The immune systems of animals and humans are different, and the immune mechanisms are not exactly the same. Therefore, if we talk about risks, the data accumulated in animal experiments are still very risky when they are used for human experiments. Therefore, even if the normal procedures are followed, clinical trials from phase I to phase III still face risks, but this risk is compliant, while the risk Yang Ping is facing now is not compliant.

If she remains absolutely rational, even if the patient does not do the K virus experiment now, she has little time left. Even if the K virus experiment fails, she can obtain the most real and valuable data, and can immediately study and modify it. In fact, the probability of success is still very high.

After thinking about it for a few days, Professor Zhang Zhiwei felt that Yang Ping's cooperation with him in this experiment was simply a pie in the sky. If Sanbo Hospital did not have a P3 biological laboratory, I am afraid that this good thing would not be his turn. His team just helped him cultivate the virus and became the main participant in the experiment. This kind of experiment, regardless of success or failure, can occupy a top position in the academic world.

Thinking of this, Professor Zhang couldn't help feeling a sense of shame for not receiving rewards without merit. He just did a little work and passively shared Yang Ping's academic achievements for no reason. From another perspective, it can be seen that Yang Ping is also a scholar who doesn't care about these false names. He only considers experiments from an objective perspective and never considers false names. Professor Zhang had deep respect for Yang Ping.

These young doctors were very happy because of this. What does it mean to participate in this experiment? It means that they may graduate with a CNS paper in their hands, and that they may complete academic accumulation that others cannot complete in decades in just a few weeks.

After the K virus preparation was packed, Professor Zhang Zhiwei and two doctors personally escorted it to Sanbo Hospital.

——

Just after the shift was handed over in the morning, the special car of Nandu Medical University had arrived at Sanbo Hospital.

Professor Zhang Zhiwei personally carried the box containing the K virus biological preparation. He came to the independent ward of the Institute of Surgery accompanied by two doctors. This ward was specially opened for Sisi to facilitate clinical trials for her. Yang Ping spared no expense for this experiment.

Yang Ping took the box and carried it to the treatment room of the independent ward. Here, Sisi and the doctors and nurses had been waiting for a long time. Sisi had made all preparations.

In the treatment room, Sisi lay quietly on the hospital bed, her eyes closed and her breathing even. Her left arm had been prepared for the indwelling needle, and her body was connected to the wires of various monitoring instruments. Various rescue equipment are also placed around, ready to be used at any time.

She was quietly waiting for the start of this new treatment. Although the outcome was unknown, she was mentally prepared for the worst, so everything seemed so calm.

"It's just like an injection. Don't be nervous." Yang Ping comforted her.

Sisi said in a calm tone: "I'm not afraid."

The ECG on the ECG monitor showed that she was indeed not afraid because her heart rate was still within the normal range and very stable with no obvious fluctuations.

"Can we start?" Professor Zhang Zhiwei asked.

Yang Ping nodded: "Start."

The portable refrigerator was opened, and Professor Zhang Zhiwei personally took out the K-virus biological preparation from it. This preparation has been designed as a disposable syringe device. When it is taken out of the sealed sterile packaging box, it can be directly connected to the indwelling needle on Sisi's arm. , and then it can be used directly as a syringe to inject the K virus liquid inside The K virus is injected into the venous blood vessels, and the K virus enters the heart along with the blood circulation in the blood vessels, and then distributes throughout the body through the arterial blood. They will selectively infect tumor cells and then parasitize in the tumor cells. Once the infection is successful, they will initiate tumors. The cell apoptosis program allows tumor cells to die quietly.

The whole process is perfect in theory. But theory is theory and practice is practice. How many drugs and treatments seemed perfect in theory, but ended up being useless after clinical testing, and were cruelly eliminated. No matter how comprehensive the treatment methods are in the theoretical stage, they are far inferior to the reality of the complex human body.

A nurse was assisting beside her. She straightened out the indwelling syringe on Sisi's arm. Yang Ping connected the preparation device to the syringe. When he was about to inject, he hesitated, looked at Sisi, and did not inject immediately.

Sisi may have felt something. She opened her eyes and raised her head slightly, and saw Yang Ping who had not yet made a move: "Don't worry, I'm not afraid." After saying that, she made a naughty face towards everyone, and the atmosphere in the treatment room instantly changed. be relieved.

Originally, Song Zimo, Xu Zhiliang and many doctors next to them had serious faces, but just now they were so amused by Sisi's grimace that they couldn't help but laugh. This little girl was so relaxed.

This K-virus biological agent was developed by Yang Ping and his team members after countless efforts, and it carries everyone's expectations. Yang Ping knew that this was Sisi's only life-saving straw, and he had to ensure that the injection process was foolproof.

Yang Ping checked it carefully again to make sure there were no problems. Then, he gently pushed the plunger of the syringe. At this moment, everyone's hearts were in their throats.

The injection began, and Yang Ping pushed the syringe carefully, fearing that something might go wrong. The viral biological agent slowly flowed into Sisi's body, as if a warm current of life was surging in her blood vessels. Everyone held their breath and watched Sisi's changes nervously.

With the injection of the virus, Sisi's expression did not change. Everything seemed so normal. Sisi felt as if she had received an ordinary painkiller injection, without any discomfort.

Yang Ping was always paying attention to Sisi's vital signs. The numbers on the ECG monitor kept beating, showing her heart rate, blood pressure, blood oxygen saturation and other important indicators. He knew that this battle had just begun. In the following time, he must remain vigilant and be ready to deal with possible unexpected situations.

After the injection was completed, everyone's tense nerves relaxed slightly, but they still did not dare to be careless at all. Sisi's condition may change at any time, and they must always stay awake and prepared.

"Get up and go back to the ward to rest." Yang Ping breathed a sigh of relief. At least there were no accidents in the early days after the injection.

Professor Zhang said while packing the portable refrigerator: "Then let's go back first and contact us anytime if anything happens."

Yang Ping thanked Professor Zhang's team and helped Sisi up. Seeing Sisi getting up from the hospital bed with great energy, those interns thought that the oppressive feeling of being faced with an enemy just now was really unnecessary. Isn't it good now? Nothing happened.

But Yang Ping knew in his heart that the real dangerous moment had not yet come. After the virus enters the human body, it takes a while for the reaction to appear, rather than immediately. Just like a cold, it often takes several days for cold symptoms to appear after being infected with a virus.

Yang Ping decided to stay vigil in the department and closely observe Sisi's changes. He knew that the next time would be their most critical test. Sisi's condition may change in a short period of time, and they must be fully prepared.

The nurses on duty worked in shifts and guarded her 24 hours a day. They were always paying attention to Sisi's vital signs and recording every subtle change.

At around one o'clock in the morning, Sisi's mother found that her daughter's body was scalding hot, as if surrounded by a ball of fire. She panicked and called a nurse, who immediately took Sisi's temperature. The results showed that Sisi's body temperature was as high as 42 degrees Celsius. This kind of questioning has reached the limit that the human body can bear. Yang Ping rushed over after hearing the news and immediately gave oral medical instructions to give Sisi an antipyretic injection.

At the same time, an ice cap and ice blanket were immediately ordered to be used on Sisi. This physical cooling method was used to protect her brain and important organs of the body. He knew that high fever could cause irreversible damage to the brain and even be life-threatening. Therefore, the body temperature must be lowered as soon as possible.

Soon, Sisi suffered from convulsions due to high fever and entered into unconsciousness. Sisi's body kept twitching and she began to talk nonsense.

Yang Ping stood by the bed and paid close attention to Sisi's vital signs, ready to deal with any possible emergencies.

All antipyretics were useless, and even the method of nasogastric feeding of Chinese patent medicine Angong Niuhuang Wan was used, but it had no effect.

The only thing that worked was the ice cap and ice blanket. The high fever lasted for a whole night. If it weren't for the physical cooling effect of the ice cap and ice blanket, Sisi would have died long ago. Yang Ping and the nurses also stayed all night. They were exhausted and their eyes were red, but they never left their posts. They knew that they couldn't slack off.

Sisi's high fever was obviously an immune response caused by the virus injected into her body. This new virus was like an alien invader to Sisi's immune system. Her immune system activated a wide range of defense mechanisms in a panic, and the body temperature regulation center was out of control, causing a high fever.

Under high fever, the oxygen consumption of brain tissue rises sharply, and blood flow accelerates, making the brain face the threat of relative hypoxia. In order to protect this most important organ, the use of ice caps becomes crucial. It physically lowers the temperature of the head, thereby slowing down the metabolic rate of brain tissue, reducing oxygen consumption, and ensuring that the brain is relatively well supplied with blood.

This process, like animal hibernation, is a self-protection mechanism. In the winter when food is scarce, animals reduce their demand for food by reducing their metabolic rate and body temperature, thus surviving the difficult times. Similarly, the use of ice caps is also a similar strategy to cope with this sudden shortage of oxygen.

Yang Ping knows that this fight is not just a battle with the virus, but also a race against time. He always maintains a high level of vigilance and carefully observes every subtle change of Sisi. Her breathing, heartbeat, blood pressure, and even every expression, all affect his heart.

Any negligence may be fatal.

But the high fever did not subside. If it continued like this, even the ice cap and ice blanket would be of no help, because the ice cap and ice blanket only provided passive cooling, and Sisi's body would sooner or later collapse in the battle between the virus and the immune system.