Chapter 1068 Disease with 100% Mortality

Berlin, Germany.

Professor Maninstein has not yet reacted. He sat in his office in a daze. On the table was a translated German paper, which was pressed by a teacup. This was Yang Ping's paper on K virus therapy.

As the leader of the German translation team of the journal "Medicine", Maninstein had completed the German translation of Yang Ping's paper on the first day of its publication. This is the immediacy of online paper dissemination. Paper papers can never catch up with this speed of dissemination. On the same day, the German paper was spread wildly in the German medical circle.

The paper was not only spread in the medical circle, but also somehow reached the ears of some tumor patients. Some patients called Professor Maninstein's laboratory to inquire about the details of K virus therapy and hoped to make an appointment for treatment. The laboratory's phone was almost blown up, which made Professor Maninstein very speechless.

I knew that I should translate anonymously and should not leave my name and the name of the laboratory. Now I dare not put the laboratory's phone away and can only pick it up and put it aside.

Professor Maninstein has not yet digested the theory of spatially oriented genes, and now Professor Yang has come up with a K virus therapy for tumors, which makes Professor Maninstein a little overwhelmed.

What on earth is this? Professor Maninstein is thinking about why it has such magical abilities.

This magical K virus uses a recombinant adenovirus to implant a protein structure called K factor. Adenovirus is equivalent to a missile, and K factor is the warhead of the missile. This missile carries K factor through the blood circulation to the tumor. Once it reaches the tumor, this recombinant new virus can infect tumor cells widely. They release K factor in the cells, just like ordinary viruses release virus particles in the cells. Once K factor is released, it can start the apoptosis program of tumor cells. Using this principle, it can kill tumor cells, and this elimination is extremely accurate. It is really a true precision treatment.

It's amazing!

Professor Maninstein exclaimed.

Each step is a fantastic idea. For example, Professor Yang's recombinant adenovirus technology is unmatched. He genetically recombined it on the basis of the existing recombinant adenovirus, almost completely avoiding the shortcomings of the original adenovirus, and making full use of its advantages, which can be regarded as a model for the use of carrier viruses.

Originally, adenoviruses like this have a very high infection rate for various cells in the human body, almost 100% infection rate, which is the biggest advantage of this virus. Yang Ping took advantage of this point. If other viruses are used as carriers, it cannot infect various cells, naturally it cannot infect tumor cells. If the purpose of infection cannot be achieved, the subsequent killing of tumor cells is out of the question.

After Yang Ping's modification, the recombinant virus maintains 100% infection of tumor cells, but the infection rate of other normal cells is reduced, that is, it will distinguish between tumor cells and normal cells, and put tumor cells on the priority of infection.

As a warhead, the K factor is a weapon that many tumor experts dream of. Many teams around the world are studying the treatment of tumors, hoping to obtain this factor, but it was easily solved by Yang Ping.

If space-oriented genes are so mysterious to most people, then the current K virus therapy is so down-to-earth that almost every professionally trained oncologist can understand it.

Professor Maninstein cheered up and immediately called his assistant: "Book me a flight to China!"

He was originally going to attend Yang Ping's wedding, but now he decided to go ahead. He wanted to see what the real situation of this experiment was like. It was so exciting.

——

Although the adenovirus-based K virus is not the best configuration now, it must be the best choice under the current conditions. We will slowly look for new configurations in the future. Through these experiments, the K virus therapy has basically taken shape. Although there are still many imperfections, it doesn't matter. We will slowly improve it in the future and improve it while doing it. Sisi's side Yang Ping has seen hope and has a glimmer of confidence in his heart. Unlike before, there is no way out in the existing treatment methods. If the traditional chemotherapy and radiotherapy continue, it will not only fail to cure the disease, but will only accelerate the deterioration of the disease.

Yang Ping made a treatment plan for Sisi, and injected K virus regularly. After K virus was injected into Sisi's body, even if it successfully infected tumor cells, it would still be attacked by the immune system. It was just that the virus that could replicate could withstand the attack for a longer time. However, as time went on, these viruses were eventually eliminated by the human immune system.

If the human body had no immunity to a virus, it would be the most dangerous. Once it started to cause damage, the human body had no ability to resist. This is why the human body was not afraid of the virus that it had been fighting with for a long time, but was afraid of brand-new viruses.

For example, viruses in frozen soil or alien viruses, once infected by humans, would be the most dangerous, because humans had no immunity to such viruses, and the human body had no experience of fighting against them. Once infected, it meant death.

The results of Yang Ping's blood test were also out. The virus had been cleared and no more viruses were found. It seemed that no matter how this virus changed, it still used the original adenovirus as the main gene. The gene determined its nature. Because of the mutation in Yang Ping's body this time, the immune system needed a certain amount of time to adjust the combat plan and slowly eliminate them.

Since the virus was cleared, Yang Ping was relieved, and everyone was relieved.

Little Zhao Yufan also received the same treatment as Sisi, because the K virus therapy was also successful in him. Now the K virus therapy is safe and effective. Yang Ping plans to recruit another group of volunteers for treatment, which can also obtain more data, and also allow the new method to benefit patients as soon as possible, so that some people can get treatment in advance. If we wait for the real K virus therapy to be available, I am afraid it will really have to go through a formal process. Even if it gets a green channel, it will take two or three years.

But thinking of the previous turmoil, Yang Ping gave up this idea again. He didn't want a similar turmoil to interfere with his scientific research.

Looking at the lively Sisi, thinking of these days and nights, Yang Ping felt that it was very worthwhile, especially this experiment gave him confidence that even without a system, he could solve the problem with his own mind.

——

Yang Ping was just about to take a break and go home for dinner, but he received a call from Professor Su.

Nandu First Affiliated Hospital invited Yang Ping to an emergency consultation. The patient was a young scientist who suddenly fell ill at home while on vacation. He was rushed to Nandu First Affiliated Hospital for treatment. He is now in the ICU due to his serious condition. The preliminary diagnosis is rabies.

Rabies has a 100% mortality rate. Perhaps because the patient's identity is too special, Professor Su must invite Yang Ping to the scene.

The emergency consultation cannot be delayed. Yang Ping set off immediately. He took the time to call Xiao Su in the car to explain the situation and could not go home for dinner.

When he rushed to the ICU of Nandu First Affiliated Hospital, the experts of Nandu First Affiliated Hospital had gathered in the conference room waiting for Yang Ping. Everyone looked serious. Director Luo of the ICU of Nandu First Affiliated Hospital immediately introduced the patient's condition to Yang Ping.

Extreme fear, fear of water, fear of wind, drooling, difficulty breathing, paroxysmal pharyngeal muscle spasm, difficulty urinating and defecation, and sweating, etc.

He was bitten by a wild dog 20 years ago, and he did not get a rabies vaccine at that time.

Yang Ping listened to Director Luo's introduction of the condition while flipping through the medical records.

Finally, the diagnosis given by Nandu Affiliated Hospital No. 1 was: rabies.

Whether it is medical history, physical examination or various auxiliary examinations, they all support the diagnosis of rabies, and there is no doubt about the diagnosis.

However, there is no way to treat the 100% mortality rate of rabies under the current medical conditions.

Yang Ping decided to see the patient first. He put on isolation clothing, gloves, and performed a set of physical examinations on the patient.

After seeing the patient, he washed his hands, took off the isolation clothing, returned to the doctor's office, and carefully read the patient's medical records again.

Rabies! There is no problem with the diagnosis.

Professor Su said: "This patient is a bit special. He is responsible for a very important scientific research task in our country. This task is halfway through. Without his participation, this project will be delayed for at least 5-10 years before it can be successful. But now this project is crucial to our country, so the superiors asked us to go all out to rescue and find ways to rescue it, and specifically asked you to participate in the emergency consultation."

Originally, Yang Ping was a surgeon and should not participate in the consultation of this infectious disease, but the superiors specifically asked him to do so, and Professor Su had to do so. Professor Su is now under great pressure.

The intention of the imperial capital was to transfer the patient to the imperial capital for treatment as soon as possible, but now the patient cannot be transferred at all and can only be treated on the spot.

"This is not any other disease, but rabies. No matter where it is, the mortality rate is 100%. There is no way. We can only do our best to let the patient live a few more days. How to rescue rabies? Now we can only treat the symptoms." Director Yuan of the Infectious Diseases Department of Nandu Affiliated Hospital was straightforward.

"Yes, some things cannot be changed by human power. Who can break the 100% mortality rate?" Director Luo also agreed with Director Yuan's opinion.

Professor Su said slowly: "Don't worry, the superiors will respect objective facts and understand us, but even if the mortality rate is 100%, we have to make 200% efforts."

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Yang Ping nodded: "Let me think about it."

If it was before, he might not say so, but after Sisi's treatment, he wanted to try any unresolved problems. Regardless of success or failure, the passion and curiosity in his mind are always ready to move.

Rabies, what else do you want with a 100% mortality rate? Any new opinions?

Everyone couldn't help but wonder what new ideas Yang Ping had. He was a genius, but geniuses were human after all.

Thanks to the large amount of time given to him by the system at that time, Yang Ping used the system space to read a large number of books and papers at that time. It can be said that he used the system space to the extreme. He read and studied alone in the system space for a long time and accumulated a lot of medical knowledge. It can be said that no one in the world would read so many of his books and papers.

Yang Ping's fingers tapped the table lightly, of course there was no sound, just a rhythm.

He thought in his heart that rabies usually died of organ failure caused by damage to the nervous system. First the nervous system was damaged, and then the organ failure. Yang Ping tried to recall the information he had read about rabies, and then summarized and refined them.

Fortunately, he was fascinated by all medical books at that time. No matter which specialty, he studied a lot. He didn't expect that a surgeon would actually participate in the consultation of rabies.

Current pathological research on rabies has found that brain damage in rabies patients is not caused by the direct attack of the rabies virus on the brain, but from complications of the disease.

Yang Ping is thinking about if there is a switch that can suspend the function of the brain, which can protect the brain from complications. It can make the brain sleep while maintaining the normal operation of the patient's immune system. In this way, although the brain has been dormant, the immune system The attack on the virus can be maintained.

In this case, while the virus is fighting the immune system, those complications will not be able to affect the dormant brain. If the virus is eliminated, will the brain be able to escape? If the brain escapes, it will not cause subsequent organ failure. In this way, the patient can save his life.

In the past, Yang Ping might have laughed at himself for his naive whims, but now he wouldn't. Wasn't Sisi saved because of his naive whims?

Anyway, rabies has a 100% mortality rate, so what’s the point of traditional treatment methods? Might as well use something new.

The cause of death from rabies has not yet been fully understood. One of the extremely important hypotheses is the "neurotransmitter disorder" hypothesis. The core idea of ​​this hypothesis is that the biomolecules in the patient's brain cannot be balanced and lead to death. There are already animal experiments showed that ketamine, an NMDA receptor antagonist, appears to serve as a bridge to balance neurotransmitters in rabies patients.

Thinking of this, Yang Ping felt that he had some inspiration and could form some ideas, but the ideas in his mind were not yet fully formed.

"It's not completely impossible. I have to think about it carefully. I'll clarify my thoughts later." Yang Ping thought about it for a long time and said this.

Yang Ping finally understood why he was able to come up with those new ideas during Sisi's treatment. It was because he had acquired a lot of knowledge by reading books in the system space. This knowledge was sometimes connected in series and combined with each other to produce some sparks of imagination.

No, boss, this is rabies with a 100% mortality rate. What can you do?

Everyone looked at each other in shock. If it had been anyone else, everyone would have laughed at it, but Yang Ping and the others did not dare because this young man is indeed a genius, and she is also the son-in-law of Dean Su.

"You give him symptomatic treatment first and try to help him delay it. I'll think about it carefully and come back later."

Yang Ping's consultation ended like this, and even Professor Su was a little confused.

On the way back from Nandu Medical University, Yang Ping was thinking about this problem while sitting in the car. With 100% mortality, can he change his mind and challenge it? There is no other way anyway, so why not try a new way of thinking? In this situation If it doesn’t work, there’s no loss.