Chapter 997

Wen Ru is posting a notice about streaking in the hospital's WeChat group. The official time is 3 pm tomorrow. At that time, he will streak around the hospital three times to fulfill his bet. This streaking is truly true.

The whole hospital is boiling over. Everyone thinks that Dr. Wen is a man who truly keeps his promise. If everyone can do what Dr. Wen does, the world will be full of integrity.

In the hospital's WeChat group, there was a lot of discussion immediately. No matter whether it is men or women, they can't wait to see Dr. Wen's real streaking. What they see is this courage and this open-minded gentleman spirit. There is a burst of fireworks in the group. If Director Zhao hadn't stopped everyone's discussion in time, the whole group would be discussing streaking.

Yang Ping has no interest in the news of his streaking. This person has a weird temper. Let him do whatever he wants. Streaking won't cause any trouble. If he is forcibly stopped from streaking, it may cause trouble. Yang Ping is very busy. He has to rush to Nandu Medical University to participate in the review of Guan Ruyan's scientific research project. The funding for this project is 50 million yuan, which is a large project in colleges and universities.

For key projects, Nandu Medical University is very strict, so a group of top scholars inside and outside the school are invited to conduct serious reviews. Yang Ping is invited as a scholar in the school, because Yang Ping is currently a candidate for outstanding young scholars and academicians, and is also preparing to compete for the Nobel Prize.

Guan Ruyan has also encountered some troubles recently. His son won the championship in the National Youth Science and Technology Competition, which was originally a good thing. But a blind reporter went to the school for an interview and caused a lot of trouble.

This interview. The principal and teacher of Guan Ruyan's son's school did not notify Guan Ruyan, maybe because the time was too urgent, or maybe because the reporter did not say that he wanted to interview the child himself, so anyway, Guan Ruyan was not notified of this matter.

After the reporter arrived at the school, the school principal and teachers were very happy and attached great importance to the interview, because it could play a certain role in promoting the school. After the reporter interviewed the principal and teachers, he asked if he could meet this outstanding child. The teacher said yes, since it was an interview, what's wrong with meeting the child himself.

Under the arrangement of the principal, the reporter met the child. Unexpectedly, the reporter majored in biology in college and was considered a semi-professional in this subject. After meeting the child, he chatted with the child casually and was surprised. The child could recite his paper skillfully and knew some of the concepts in it, but it was obviously memorized, because after a little questioning, the child knew nothing. Then the child was very honest and said that the paper was written by his father and told him to memorize it. He did not participate in the experiment, but he went to the laboratory several times to take many photos.

This matter was written into an article by the reporter and published on the Internet, which immediately exploded. How did the promised youth science and technology competition become a competition for parents behind the scenes? Is this competition still meaningful? Of course it is, this is the capital for future admission to higher education, and the competition is no longer a simple competition.

This incident had a huge impact, because the identity of the child's parents was finally revealed. Both parents were professors at a medical university, and the son was a primary school student. He took a medical paper to participate in the competition. You can imagine what happened. In fact, some people questioned it at the time, but the organizer announced that after investigation, the doubts were confirmed to be rumors. The contestants' experiments and papers were completed independently, and there was no fraud, so the doubts were left unresolved.

Everyone couldn't help but sigh that other people's children were smart. Their own children couldn't even understand how to do homework, while other people's children were able to publish papers in internationally renowned medical journals and do high-tech experiments. Alas, the gap was too big.

Yang Ping came to the conference room of Nandu Medical University. There were still a few minutes before the meeting started. The experts and professors who were reviewing the meeting had almost arrived. Guan Ruyan had arrived in advance. Sitting next to Guan Ruyan was his assistant Lu Xiaolu.

Guan Ruyan looked haggard, and it was obvious that he had been very troubled by his child's affairs recently. Now there was a lot of calls online to investigate this matter and cancel the child's championship.

"Professor Yang!" Guan Ruyan greeted Yang Ping.

Hearing that Yang Ping was coming, many professors in the conference room stood up to welcome him. Yang Ping smiled and bowed to everyone, then sat down in his seat.

Several professors who arrived later also arrived one after another. Finally, President Rao and Academician Xiang came into the conference room together, and everyone stood up to welcome them.

Guan Ruyan's project is about CAR T cell therapy. At present, Americans are ahead in this field. Guan Ruyan wants to use this project to catch up with the cell therapy technology in the United States. Yang Ping looked at the general idea of ​​the project. Indeed, the idea is relatively novel. If it can really succeed, it can greatly shorten the gap with them.

Not long ago, Yang Ping used cell therapy to treat a tumor patient and achieved great success.

But Yang Ping's main focus is not here. It is impossible to study everything, so he communicated some of the results of cell therapy with Lu Xiaolu. Lu Xiaolu is very smart. Not only does he understand the meaning of this project, but he can also conduct some research along the line of thought.

When communicating with Lu Xiaolu before, Yang Ping felt that his research in this field was very deep. In this topic, almost all the new ideas proposed by Lu Xiaolu at that time can be seen. So, are these ideas Lu Xiaolu's or Guan Ruyan's? This made Yang Ping a little confused.

The meeting started on time. All the people present were bigwigs. Some were invited by friendly schools, some were from our school, and there were two international friends. So the meeting was still relatively formal. Although there was a human element, it was not much.

"Let me introduce the basic situation of this topic first -" Guan Ruyan knew the importance of this meeting. It would obviously be a lack of respect to let his assistant introduce it, so he went to the battle in person and needed Lu Xiaolu's help when necessary.

Because this project was completely designed by Lu Xiaolu, the idea is his, the details are also his, and he also wrote the final project plan. Guan Ruyan has been very busy recently, with many academic conferences to attend, and his son's affairs to deal with, so He had only recently become familiar with this topic. It was inevitable that the experts attending the meeting would be ruthless and serious, so Lu Xiaolu could help deal with it at critical moments.

"The T cells isolated from white blood cells are added with specific chimeric antigen receptor genes, modified into the CAR T cells we want, and then placed in the laboratory to grow and multiply, waiting for them to be transformed into cells that can recognize And destroy the warriors of cancer cells. At this time, we inject them into the blood of the human body and reach the target tumor through blood transportation. These special warrior cells recognize and kill tumor cells. This is the common practice of CAR T cell treatment of tumors in the world. "

"CAR-T therapy, as a revolutionary tumor treatment method that uses genetic engineering technology to modify the body's own immune cells, has brought new hope to countless patients with blood cancers, but there are currently unavoidable problems - using CAR -T cells cannot treat solid tumors because solid tumors lack binding antigens related to blood tumors, which prevents CAR-T from recognizing and targeting solid tumor cells.”

''Our project is to solve this problem - using a special CAR-T cell to treat solid tumors. If successful, this will be a huge breakthrough. "

After Guan Ruyan briefly introduced the topic, the audience burst into warm applause. I have to admit that this topic has captured the biggest pain point of CAR-T therapy. Currently, many pharmaceutical companies promoting CAR-T therapy are investing heavily in research on this topic. Pain points, but there is no obvious breakthrough for the time being, and Guan Ruyan’s project solves the pain points of CAR-T therapy from a new perspective. If successful, it can expand the indications of CAR-T therapy, which is a great benefit for both patients and pharmaceutical companies. Good news.

"Professor Guan, if you use CAR-T therapy to treat solid tumors, can you disclose the specific implementation method? We know that because CAR-T cells are currently limited to blood cancer treatment, because most solid tumors lack the ability to interact with CAR-T cells. Cell-bound antigens cannot be recognized and eliminated.”

"Although neoantigens, a class of HLA-binding peptides resulting from tumor-specific mutations, are highly immunogenic, since they are not present in normal tissue, they can bypass central thymic tolerance and avoid Common problems with selecting antigen targets for CAR-T cell therapy, but they are not suitable for large numbers of patients.

"In addition, even after the optimal antigen target is selected, the function of CAR-T depends on factors such as the ability to prevent tumors from escaping immunogenic epitopes. That is, there is still the possibility of tumor escape, and these factors are all This results in the therapy being less effective in solid tumors."

"Do you think that when CAR-T cells are combined with targeted drugs, CAR-T cells express a special cell surface protein for drug-resistant persistent cells, which can more effectively delay the emergence of complete drug resistance--"

The expert who asked a series of questions was Professor Shen Xuebin from the Imperial Capital. Professor Shen is a professor who has returned from studying abroad. He is a talent introduced by the Thousand Talents Program. He is very optimistic about this project and has admired Guan Ruyan's talent for a long time. This time he just took this opportunity to meet with Guan Ruyan. Communicate in person.

"Our idea is to modify the new antigens into antigens that can appear widely in certain solid tumors, so that the scope of application can be expanded." Guan Ruyan replied with a smile, and then took a sip of water.

"I mean how do you achieve modification and what modification tools do you use? I don't think there is a way to do it with the currently known antigen modification tools. What unique insights do you have on the application of modification tools? Secondly, how to avoid the possibility of modification with new tools? Controllability, so that it does not produce some negative reactions that are out of control, because almost all new tools face the problem of out of control. "

Indeed, Guan Ruyan did not study deeply on the issue of grooming tools. Lu Xiaolu had always been in charge, so he took another sip of water and cleared his throat: "I'm sorry, I'm sorry, I've had a cold these past two days and my throat isn't very good, Xiaolu, Please introduce the details of the modification tools to everyone.”

In fact, few people are so serious about this kind of meeting. It is obviously inappropriate to hold on to these details and insist on asking the truth. We are all friends in the same circle, and we have to be merciful and merciful. Next time it is our turn, What should I do if others ask sharp questions like this? However, Professor Shen is an upright person. He is very interested in this topic and has many questions in his mind. Today is a rare opportunity for face-to-face communication. Naturally, he has to clarify the questions. He did not let Guan Ruyan know at all. Embarrassing meaning.

Lu Xiaolu immediately took over: "Professor Shen asked very well. Our modification tool is a brand-new modification tool. This tool is tailor-made for this project, -——"

Next, Lu Xiaolu answered Professor Shen's question in detail. Professor Shen nodded, very satisfied. His guess was indeed correct. The other party used a brand new modification tool, but the idea of ​​the tool surprised him. He hadn't thought of it before.

"You had a professor at Heidelberg University in Germany who proposed this idea, but it has never been realized, right?" Professor Shen has a wide range of knowledge.

Lu Xiaolu immediately said: "That is my doctoral supervisor. I continued to study along his line of thought. Oh, Professor Guan led me to continue to study along his line of thought, and finally succeeded this year, so we started the current project."

Lu Xiaolu found that he almost crossed the line, so he handed the initiative to Guan Ruyan: "If Professor Guan was not in poor health today, he would explain the modification tools more deeply. My understanding of the tools is far less than that of Professor Guan."

Guan Ruyan was very satisfied with Lu Xiaolu's performance. This guy is very smart and can always give himself a great assist. Then Guan Ruyan added some gorgeous words, which was a summary of Lu Xiaolu's speech.

"Professor Guan, I feel a little uncomfortable in my stomach. I will go out for a while. Ten minutes at most." Lu Xiaolu suddenly felt unwell and asked Guan Ruyan for a temporary "leave".

Guan Ruyan immediately nodded and allowed it. This kind of thing must be allowed even if it is not allowed. It is impossible for him to pull in his crotch.

"Your new modification tool is very clever. I am curious about how the modified antigen can be persistent at the binding site. It is said that your type of new antigen has a common feature, that is, the lack of binding persistence. I wonder how Professor Guan solved it."

Another professor invited from the United States was interested in another question and asked the question in English.

"In our previous research, we found a new expression protein that helps the persistence of binding. So this time we will simulate the mechanism of tumor cells releasing expression proteins. When the new CAR-T cells bind to the new antigen, they will release this expression protein, so that the binding can be persistent."

"We have also studied this expression protein, but it is not extensive. It is easy to fail to express in many scenarios. How do you solve the problem of expression failure, that is, how can they be accurate and sensitive in identifying the scene and timing of expression, and how can they fully display the expression after the expression is started?"

This question is probably very complicated to say. Guan Ruyan did not have time to understand it thoroughly at the time, because this problem is not a window paper problem, but involves the cross-application of many current cutting-edge technologies.

"This issue is very complicated and involves the cross-application of many cutting-edge technologies. If it takes a lot of time to explain, is that okay? I will explain it to you in detail after the meeting." Guan Ruyan glanced to his side, wondering why Lu Xiaolu hadn't come back yet.