Chapter 871 Generic Drug Company

"Manman, you don't know the darkness in the pharmaceutical industry~"

"I really don't know, but you haven't told me~"

"You never asked~"

Lin Ximan's tone froze, she bit her lip and stared at Wang Lei with red eyes.

The two of them were like children, you glanced at me and said something, and there was no reason for the dispute.

Wang Lei lowered his head, his expression was full of resentment and helplessness, he was silent for a while, and then said quietly, "The major pharmaceutical companies in the United States spend a huge sum of 6 billion U.S. dollars every year on their so-called doctor training programs, and these training contents But what? Either expensive gifts for doctors or free luxury holidays for them.

The minds of these companies are not on pharmaceuticals at all, but on how to attract hospitals and doctors. As long as the medicines produced by the company are bought, the effect is not important at all. As for the patents I took, they are worthless, because they invested in bribes. More money than is invested in drug development~”

Paused, took a sip of coffee, and continued, "Just last June, in the world-famous Museum of Modern Art in New York, our colleague, a pharmaceutical company, held an extremely luxurious weekend party, and the scene was heavily guarded. The layout is extraordinary, and of course the boss of the pharmaceutical company is not worried about it, because all the expenses will be included in the cost of the medicine.

The doctors who had been invited by the drug company to New York for the weekend and to attend a medical seminar later in the day seemed to be in high spirits.

Because they don't need to spend a penny for this trip, all the expenses are paid by the pharmaceutical company, and there are unexpected surprises, they only need to publicize the new drug promoted by the company in the future.

And the research and development cost of the main drug this time is only 20 million US dollars, which also includes a lot of manpower expenditure. Of course, this drug will not kill people, but it will not help the disease. "

"Not only that, but they would rather hand over precious R&D funds to special commissioners for liaison with doctors. There are about 80,000 such people in the United States. Their work is very trivial, and they have to communicate with doctors frequently. To give gifts to doctors quietly, the most important job is that they should guide doctors at any time, which new drug should be prescribed to patients when prescribing.

Drug companies can be said to be everywhere, and even the annual general meeting of the American Medical Association, the most prestigious medical organization in the United States, cannot escape their gift bombardment.

In addition, the AMA receives $2 million in annual sponsorship from pharmaceutical companies to hold a drug expo during the AMA annual meeting.

After all, today's healthcare system is like a big business. From R&D to hospitals and pharmacies, everything is measured in money. We R&D personnel have no right to speak at all, let alone talk to the forces Powerful pharmaceutical companies have resisted, and the final outcome is a dead end, and there will be no second way.

Last year, a colleague was unwilling to be reconciled to the results of his hard research and development being taken away by the company. He contacted several lawyers to file a lawsuit against the company, but before he entered the court, his lawyer told him that the lawsuit was useless and could only be for nothing. Waste of money, the company has already made perfect preparations, colleagues insisted on fighting, needless to say, in the end, not only did the results not get back, but also paid a large amount of compensation to the company, and in the end they couldn't even keep their jobs. A ban order was issued, and there was no source of income,

His wife and children have separated, and he is still working as a coolie in a car wash. "

The cruel reality revealed by Wang Lei made Lin Ximan temporarily shut up, but cast a hopeful look at Yang Cheng.

Yang Cheng smiled wryly, "To be honest, I don't know much about the pharmaceutical industry, at most I just speculate on the shares of some pharmaceutical companies, and I don't know anything about the inside story. Of course, I don't know much about the darkness of the entire healthcare system. I’ve heard it before that I’m powerless to change anything, even if I could change it, I wouldn’t do it, after all, there are huge benefits and multiple interested parties here, I don’t want to try to hit a stone with an egg.”

After a pause, when Lin Ximan felt a little lost, he changed the subject, "However, for your sake, I can help a little. Before that, I have to ask Leizi a few questions~"

Wang Lei nodded again and again, "Just ask~"

Yang Cheng organized his speech, "Do you still have unpublished patents in your hand? Or an invention research that will produce results soon?"

Wang Lei hesitated for a moment. After all, he couldn't resist the temptation of love. He nodded and admitted that he still had a lot of dry goods in his hands, but he reminded, "Do you want me to develop new medicines?"

Yang Cheng nodded without hesitation, "I have a good relationship with the medical center. It is not a big problem to find a sales channel. As long as the first model is successfully launched and has effective curative effects, the future will be much easier. .”

When it comes to professional issues, Wang Lei is cowardly, his eyes are like lightning, he looked at Yang Cheng with a sparkle and said, "It is very difficult. You are not in this industry and you don't know anything. One of the usual methods used by pharmaceutical manufacturers today is to apply for patent clusters." , which means to apply for multiple patents for the same drug, and the craziest one even applies for as many as 1,300 patents for one drug.

The significance of this approach is to minimize the patent validity period of its drugs to prevent similar drugs from entering the market.

Including industry giants such as Pfizer, GlaxoSmithKline and Sanofi-Aventis, their R&D teams are strong and rich, as long as they find a competitor, they will not spare money and time to initiate lawsuits to interfere with the rhythm of the opponent's drug launch , taking advantage of this period of time, vigorously imitated the drug, and pushed it into the market before the lawsuit came to fruition. With better public relations capabilities, the original manufacturer of the drug could only walk towards the fate of being acquired in tears.

The giants do this kind of thing every day. They often take their opponents to court in the name of infringement of their patent rights, and patent disputes will take at least 3 years to produce results, which is not necessarily in your favor.

There is another common method, as mentioned before, to make private agreements with small companies, use money to buy rivals, and get them to agree to restrict their own drug sales, or give them the right to sell them. "

Yang Cheng's brows were deeply frowned, and she rubbed her chin, "That means we can't get around the suppression of pharmaceutical giants including Pfizer no matter what?"

Wang Lei spread his hands, "Anyway, I can't help~"

The stubbornness in Yang Cheng's bones has been committed again. Pfizer is a giant, but it doesn't mean he can't, he is also a giant himself.

Wang Lei suddenly slapped his forehead, "Actually, there is no way out, Mr. Yang, do you know about generic drugs?"

Yang Cheng spread his hands, obviously he didn't know anything about this vocabulary, but he could probably guess that it was nothing more than a copycat beautification vocabulary?

Wang Lei seemed very excited, "First of all, we must understand that generic drugs are not counterfeit drugs. The so-called imitation refers to the imitation of existing innovative brand drugs. Generic drugs are completely equivalent to brand-name drugs in terms of pharmaceutical indicators and therapeutic effects, but they are different. The difference is that generic drugs are often named after the chemical names of their active ingredients.

As far as the U.S. market is concerned, generic drugs generally enter the market after the patent protection of branded drugs expires, and their prices are much lower than branded drugs. The most important thing is that generic drugs are subject to the same strict ZF regulations as branded drugs. The US Federal Food and Drug Administration The FDA (FDA) has a generic drug office to manage it as a whole, that is to say, it is reasonable and legal to develop and sell generic drugs! "

The more Wang Lei talked, the more excited he became, because he saw the dawn of success in pursuing Lin Ximan, and Yang Cheng heard the wonderful sound of gold coins falling into the bag.

"Moreover, in the next 10 years, the number of patent expirations of patented drugs will show explosive growth. It is conservatively estimated that in the next 5 years, the total value of branded drugs facing patent expiration will exceed 250 billion US dollars. If the price of generic drugs in the past is Judging from the proportion of 10%-20% of patented drugs, the generic drug market is expected to increase by 25-50 billion US dollars, and the profits are quite considerable.”

Yang Cheng became more and more interested, and turned sideways, "Can you tell me the specific operation method?"

Wang Lei didn't bother to observe the looming admiration in Lin Ximan's eyes, and said with gestures, "I don't know much, but if you want to enter this market, you can roughly divide it into two ways: first, establish Foundry, recruiting a large number of ethnic minority workers, relying on cost advantages in exchange for distribution of agents in the channel;

Second, self-built sales teams, directly facing pharmaceutical wholesalers, retail pharmacies, and pharmacy welfare management agencies (PBMs) responsible for drug price negotiations, relying on brands and product lines to strive for greater profit margins.

However, the two ways of agency or self-operated have their own advantages and disadvantages.

If self-management is adopted, it will be directly connected to the terminal, and the drug needs to apply for a wholesale license to enter the market of each state, and the regulatory issues it faces are also very cumbersome.

Of course, we can entrust it to an agent, which is a good way to simplify regulations and audit procedures. After the drug is launched, the company will obtain the national drug verification number and logo of the agent, and the distributor will be responsible for direct delivery to the pharmacy.

Although the licensing application and sales process has been simplified, pharmaceutical companies will be constrained in terms of drug pricing, sales strategies, production scheduling, and market control. We can't intervene in any direction, we can only make hard money.

There is no initiative at all. Once an order is received, it must be produced immediately. There will also be cases of three-day netting and two-day fishing, and temporary cancellation of orders. Tons of raw materials have to be shelved in warehouses, and these are issues we need to consider. "

Yang Cheng nodded, and summed up brilliantly, "Instability and low profit are the biggest problems of this plan, but the advantage is that it is easy to enter the market, and the process is relatively simple, you continue~"

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