Chapter 668 Appropriations, 5 Billion!
"Rejection reaction!"
This is actually the most difficult hurdle for all organ transplants.
The key to a successful liver transplant is also this. Only by controlling immune rejection can the donor liver survive and function in the new body.
The three days after surgery are the period of high incidence of acute rejection reactions. The main symptoms include fever, lethargy, upper abdominal pain, jaundice, etc. The sensitive laboratory indicators coincide with the liver function tests emphasized previously, which are serum aminotransferase and alkalinity. Elevation of phosphatase and bilirubin.
Three days later, and up to three months after the operation, acute rejection may occur again. Only after this period of time has passed, the dangerous period is over.
The leader of the nursing department asked: "Dr. Xu, where is the anti-rejection plan?"
"Methylprednisolone, cyclosporine A, and azathioprine."
After thinking for a while, Xu Qiu added: "The starting dosage of methylprednisolone is two hundred milligrams per intravenous injection for four days, and then it is gradually reduced by forty milligrams every day, and finally maintained at a dose of twenty milligrams.
"Cyclosporine A is five milligrams per kilogram of body weight. Azathioprine is one milligram per kilogram of body weight.
"Routine postoperative examinations plus a liver B-ultrasound!"
When acute rejection occurs, the size of the donor liver will increase rapidly. At this time, the diagnosis can be easily made through B-ultrasound.
"Yes!" The head of the nursing department nodded solemnly.
"How's the situation in operating room No. 1?" Xu Qiu suddenly asked.
The circulating nurse immediately said: "Operating room No. 1 stepped down an hour ago. The patient has woken up and been sent to the ward."
Qiu Qinghu only removed 60% of his liver and closed his abdomen, so there was no serious problem.
But Fang Wenwen was different. She had the entire diseased liver removed and a new liver transplanted despite her poor physical condition. She also needed to ensure that the donor liver survived and restored its function after surgery, which was much higher than Qiu Qinghu's.
Therefore, you need to stay in ICU for a while.
The circulating nurse said worriedly: "Doctor Xu, the powerful morphine is of no use to this Qiu Qinghu..."
The anesthesiologist was also shocked and said: "Well, during the operation, the amount of anesthesia he used was almost 1.5 times that of a normal person, which is unimaginable."
Professor Chang, Academician Zheng and others who had not spoken had a stunned look on their faces, "Morphine doesn't work?"
How can it be!
Before the operation, they all followed Xu Qiu to do a preoperative examination on Qiu Qinghu. At that time, they found nothing unusual.
I didn’t even see how much pain Qiu Qinghu showed!
The nursing team leader sighed: "He is used to it. If his wife hadn't also been diagnosed with cancer, he might not have come to the hospital now. It was only after Dr. Xu performed the metacarpal finger regeneration surgery that he had the opportunity to take medicine for free. "
Professor Chang and others immediately fell silent.
Can cancer pain that cannot be suppressed even by morphine really be resisted by human willpower?
Academician Chen, who came from a poor era, sighed quietly: "Be poor, what pain is more painful than poverty."
Everyone stayed where they were, feeling like their hearts had been hammered hard.
…
After the operation, Xu Qiu ordered a box lunch and had a simple meal.
Without enough time to rest, he rushed to Baiyun Pharmaceutical Factory again.
One of the most important reasons why Baiyun Pharmaceutical Factory was originally chosen as the base for research and development of new drugs was that it was located in Linhai City, only about 40 minutes' drive from Linhai No. 1 Hospital.
Baiyun Pharmaceutical Factory occupies a large area, with more than 1,300 acres of construction land. It covers everything from drug research and development, pharmaceutical industry, clinical trial base to pharmaceutical warehousing and logistics. Although its operating conditions are not very good and there are no star products, it covers everything. .
"Doctor Xu!"
As soon as the special car arrived at Baiyun Pharmaceutical Factory, Chairman Shi Wang opened the car door enthusiastically.
Behind him were a group of pharmaceutical company executives, all wearing suits and leather shoes, with warm and respectful attitudes.
Baiyun Pharmaceutical Factory has a large scale, but its profitability is extremely poor, and it has even been losing money. The pharmaceutical factory has also tried reforms internally, but its excessive scale also means that innovation is extremely difficult...
Xu Qiu gave Baiyun Pharmaceutical Company the qualification for new drug research and development, which was tantamount to giving them a chance to change their fate!
Therefore, Shi Wang and others had to build a golden body for Xu Qiu as an offering.
"You don't need me to greet you every time I come. You are busy with your own business." Xu Qiu declined the enthusiasm of Shi Wang and others.
"Just send it here." In front of the Drug Research and Development Institute, Xu Qiu waved her hand and walked straight in.
Seeing Xu Qiu's back completely disappearing into the research institute, Shi Wang slowly put away his smile and said with emotion: "Dr. Xu's aura is so strong. I have come into contact with many big names, but none of them are like him. There is a calmness and calmness that comes from within.”
The deputy director admired: "It is a genius who was protected by two ministers. The Minister of Health and the Director of the National Health Commission jointly approached the National Finance Bureau and asked for an allocation of 5 billion. This is 5 billion. !”
The state's annual financial allocation to Tiandu University and Qinghua University is less than 10 billion, which are still the two top universities in the country.
It stands to reason that no matter how outstanding Xu Qiu is, it is impossible to get funding comparable to that of top universities.
But, behind him, there are two ministers guaranteeing their positions!
Giving out 5 billion in one breath not only showed trust in the two state-level officials, but also valued Xu Qiu.
"The cost of our generic drugs may be more than one billion, let alone an original drug... Is five billion really enough?" Someone frowned deeply.
Schwang glanced at the financial director and asked, "How much money do we still have on our account?"
"Very little." The financial director said helplessly.
Last year, the operating income of Baiyun Pharmaceutical Factory was only a little over 10 billion, and the net profit attributable to the company was about 800 million.
Now, the working capital that the pharmaceutical factory can mobilize is about 100 million.
The total turnover of the pharmaceutical factory is only twice the research funding of Xu Qiu, and the money that can be used is really a drop in the bucket.
Shi Wang was silent after hearing this. He thought for a long time and suddenly said: "Then sell it!"
Everyone was shocked.
Shi Wang continued: "Everything that can be sold has been sold. What Dr. Xu can't use can also be sold by the pharmaceutical factory. The production lines of Baiyunling and Baiyun Compound Pharmacy can be transferred!"
The vice chairman's face changed drastically: "This is one of the few products in our group that can make money."
Others also worried: "Shareholders will not agree."
Shi Wang said: "Look at Dr. Xu's Linhai small blood vessels, how terrible is the current profitability! If we miss this opportunity to participate in Dr. Xu's new liver drug, we may never wait for a real take-off again!"
Everyone's expression was stern, and their mood suddenly became excited.
"Then hold a shareholders' meeting and sell it!" The vice chairman also clenched his fist... This time he's risking his life!
Xu Qiu's R&D site selection opportunity is something that top domestic pharmaceutical companies such as Harbin Pharmaceutical and Guangzhou Pharmaceutical are dreaming of, even the state-owned Daxia Pharmaceutical Group Corporation, but now it has fallen to the third-rate Baiyun Pharmaceutical Factory...