Chapter 371 Success Is Imminent!

This sudden discovery made Chen Nan suddenly excited.

Clinical significance of XIAP-associated single-gene mutant Crohn's disease in adults.

It may even be related to the pathogenesis of Crohn's disease patients.

In Chen Nan's mind, the ideas and clues for the next research, as well as the follow-up research plan, came up in his mind.

First of all: how to use traditional Chinese medicine to alleviate the predisposing factors of the disease, prevent the development and deterioration of the disease, and cooperate with concentrated Chinese medicine enemas and external medicines to treat the already formed intestinal inflammation.

Second: For patients at risk of Crohn's disease, gene sequencing is performed, and then the XIAP gene is found, and traditional Chinese medicine is used to prevent it, so as to prevent the occurrence of the disease and achieve the purpose of preventing the disease before it happens.

However, no matter which one, it is definitely of great significance to patients.

The most important factor of Crohn's disease is persistent disease. If more targets can be found based on the already discovered XIAP gene, it may be useful for the treatment of Crohn's patients or for recurrent attacks of the disease. Have a significant effect.

Chen Nan is well aware that Crohn's disease, like hypertension and other diseases, is not a problem that can be solved by the current medical level.

But even so, it is already a great progress to relieve symptoms, avoid triggers, control the symptoms of Crohn's disease patients, and avoid recurrence.

Thinking of this, Chen Nan hurriedly got up and drove to the hospital.

Here, he just entered the doctor's office, and was about to talk without thinking about changing clothes, but saw how many people were in the ward? And they were all wearing white coats, Chen Nan was stunned for a moment.

"This is……"

Chen Nan looked at the two people in front of him, seemed a little unfamiliar, and asked curiously.

Before Zhao Jianyong could speak, the man on the side walked decisively and introduced himself.

"Director Chen, hello, I'm taking the liberty to bother you today. Let me introduce myself first."

"I am the director of the Gastroenterology Department of the Western Medicine Ward of our hospital, Sun Jinxiao, and this is my deputy director, Xu Maoxuan."

"Today's visit, not for anything else, is that we want to join your Crohn's disease research center."

Sun Jinxiao straight to the point explained the purpose of coming, with sincere eyes and a sincere attitude, Zhao Jianyong shrugged at Chen Nan and did not speak.

Chen Nan's brain is still a little dazed now. After all... During this period of time, inside and outside the hospital, the attitude towards his sudden establishment of this research center is not very good, and the evaluation is not very high.

What's the matter...the gastroenterology department of the western medicine ward came here?

He knew about the Department of Gastroenterology in the western medicine ward, which is also a national key specialty, with a high level, but as the director, how could Sun Jinxiao's level be poor?

So... Chen Nan still didn't understand, but he said politely:

"Oh... Director Sun, hello, hello, sit down quickly, by the way, pour Jianyong a glass of water, and speak slowly."

Hearing the sound, Sun Jinxiao waved his hands at Chen Nan and Zhao Jianyong: "Director Chen, you don't need to drink water. If you come here to drink tea or do other things, you don't need to."

"I came today with sincerity."

"Our department has a long history of research on Crohn's disease. Although there have been no outstanding achievements in these years and no awards in this field, the basic research is in place."

"Director Chen, I believe that our joining will make the progress of this experiment smoother and save you a lot of trouble."

"Of course, don't worry, after we join, we will also bring in relevant staff for clinical cooperation. Our nurses and doctors are all professionally trained."

"I won't hold you back!"

Chen Nan could hear Sun Jinxiao's sincerity, and Chen Nan really needed help at the moment.

If clinical trials are to be carried out, it is definitely not something that a few people can complete.

If there are gastroenterologists who are professional in the field of Crohn's disease, this is definitely good news for the experiment.

Right now, with the discovery of XIAP-related single-gene mutant Crohn's disease in adults, related work needs to be carried out immediately. If the gastroenterology department of the western medicine ward joins in, it will save a lot of time.

only……

Chen Nan hesitated, after all, they are about to make progress now...

At this time, Sun Jinxiao handed over a stack of materials in his hand: "Professor Chen, these are the materials we prepared. You can take a look to see if we are qualified to join your project."

Sun Jinxiao naturally saw Chen Nan's doubts. In fact, not only Chen Nan, but any research group in the world has strict requirements for personnel selection and joining.

If you don't have strong strength, why should you?

After speaking, Sun Jinxiao took Xu Maoxuan and left without paying any attention to what was left for Chen Nan.

Xu Maoxuan was reluctant, turned around every step of the way, wanted to speak, but was stopped by Sun Jinxiao.

After leaving, Xu Maoxuan couldn't help but said, "Director, is this just for him?"

"We have studied for a long time..."

"Also, maybe we can find something special too?"

"Besides, from Chen Nan's attitude, you have made it clear that we are not welcome."

"We are so humble...why bother..."

Sun Jinxiao shook his head: "No, it's different."

"We are applying to join, and we need to come with sincerity and ability. If Director Chen comes and welcomes you directly, I will not only not be happy, but I will only feel a little worried. After all... a strict research group must be almost harsh on personnel control .”

"You can't just come and join."

"Besides, our research is quite embarrassing..."

"Forget it, if Chen Nan is willing to believe in our ability, or value our research, it is not a bad thing for us to join."

"If you don't understand or don't like it, we will do it ourselves!"

...

At this time, in the doctor's office, Chen Nan was also full of curiosity about Sun Jinxiao who made a sudden visit and left behind research materials.

Zhao Jianyong hesitated and asked, "Director Chen, what do you plan to do?"

Chen Nan looked at Xue Zhongqing at the side: "Director Xue, please introduce this Director Sun to me."

Xue Zhongqing nodded: "Actually, Director Sun's reputation in the hospital is actually very good, and this person rarely asks for help. To be honest, I am also very curious why Director Xue would take the initiative to apply to join."

"It's so rare."

"Director Sun is very capable. He has been engaged in clinical work for more than 30 years, and has participated in the research of inflammatory bowel disease many times, but... rarely wins awards."

"To be honest, Director Chen, I feel that Director Sun came here with sincerity. However, you should read these materials first before making a decision."

Chen Nan nodded: "Well, good!"

Chen Nan flipped through these materials, and prepared to put them in the office, and read them later, and went to the ward rounds first.

But... after seeing this, Chen Nan was stunned.

The content in these materials immediately attracted Chen Nan's attention.

"Study on the benefit of early treatment in Crohn's disease."

Chen Nan was instantly attracted by these words.

Because of this study, there may be important overlaps in the follow-up research.

It can't even be avoided by oneself.

Early treatment!

This is a new concept beyond the imagination of Western medicine.

To be honest, Sun Jinxiao's ability to propose such a new concept made Chen Nan instinctively excited.

Sure enough, in the China-Japan Friendship Hospital, in the border of the capital, it is really Crouching Tiger, Hidden Dragon.

Chen Nan decided to look at the other party's research first, and then go to the ward rounds.

Thinking of this, he said hello to Zhao Jianyong: "I have something to do, you should do it first."

While speaking, he got up and carried Sun Jinxiao's documents and entered the room.

He quickly unfolded the information and read it carefully.

There are a lot of information in it, including projects, application project records, and clinical trial results.

What Chen Nan discovered just now was an application report for a special project.

After Chen Nan opened it, he looked at it carefully.

"Crohn's disease (CD) is a chronic progressive intestinal inflammatory disease with recurrent symptoms that can lead to intestinal damage and, in severe cases, can be disabling.

Although the use of biological agents represented by anti-tumor necrosis factor (tumor necrosis factor, TNF) has changed the clinical outcome of some patients, more than half of the patients still require surgical intervention, and 50% of patients have clinical recurrence after surgery , 80% had endoscopic recurrence, and 30% had surgical recurrence.

Therefore, I propose the study of early treatment of CD disease.

I will define early treatment, evaluate its clinical benefits and risks, and combine the research progress of CD in recent years to further analyze the research elements and provide reference for domestic counterparts. "

Chen Nan looked at it seriously.

Sun Jinxiao found through clinical research that patients who received drug treatment within 18 months of diagnosis had better treatment outcomes, lower surgical risks, and better disease prognosis than those who received treatment 18 months after diagnosis.

And he mentioned one point, that is, if the disease can be intervened in time before the disease is discovered, it is the best thing.

Even, for the research of early treatment, Sun Jinxiao made a strict distinction.

Including precipitating factor phase treatment.

The period of suspected symptoms, the period of confirmed symptoms...etc.

In fact, early treatment is very difficult, because the onset of Crohn's disease is mostly hidden, and it often takes months to years from the appearance of early symptoms to the diagnosis.

The course of the disease is chronic, with periods of activity and periods of remission alternating in varying lengths, and there is a tendency to relapse throughout life.

Therefore, if early treatment is proposed, it is easy to be denied.

Sure enough, when Chen Nan saw the expert feedback at the end of the project, he saw the words "disagree" and "deny".

Undoubtedly, the above does not approve of Sun Jinxiao's point of view.

"Evidence for early treatment mostly comes from drug clinical research, which lacks the support of prospective controlled research results, and there are two aspects of over-treatment and lack of economic benefits. After perfecting the research..."

This is the opinion of the experts.

And there are many papers behind Sun Jinxiao, all of which are about the ideas and plans of early treatment.

Chen Nanyue looked more and more excited.

This Sun Jinxiao may coincide with his next research.

What's more, with his joining, my own research will instantly become full and form a complete project.

And Sun Jinxiao will definitely prove his early treatment philosophy by joining him.

It's a win-win!

At this time, Chen Nan picked up the phone and dialed Sun Jinxiao's cell phone.

At this time, Sun Jinxiao was sitting with Xu Maoxuan in the office, waiting for news from Chen Nan.

To be honest, Sun Jinxiao has no idea in his heart.

He didn't know if Chen Nan had such foresight, or if he recognized his idea of ​​"early treatment".

Xu Maoxuan sighed: "Director Sun, I think...you are too honest, and even gave Chen Nan the original opinion rejected by the professional committee."

"After seeing this, Chen Nan won't laugh at us?"

Sun Jinxiao remained silent, joke? Sun Jinxiao never thinks that he has done wrong.

It can only be said that the current level, the level of the professional committee, is not necessarily high.

Sun Jinxiao is a proud person, but also a person with backbone and enough self-confidence.

Perhaps in the eyes of others, Sun Jinxiao is older than Yan Jiaheng and the others, but not as fast as others.

But...Sun Jinxiao has always stuck to his principles and ideas.

Status, he doesn't care.

What he cares about is whether he can really make achievements to benefit patients.

Sun Jinxiao said frankly: "Maoxuan, what we are looking for is a like-minded partner, not a colleague who seems to be close to each other."

"If Chen Nan doesn't agree, I have nothing to say, but it will save me a lot of trouble."

At this moment, the phone rang suddenly.

Sun Jinxiao looked at the caller ID, it was not marked, but he picked it up anyway.

"Hi, I'm Sun Jinxiao."

A voice quickly came from the phone: "Director Sun, are you busy? I'm Chen Nan."

Sun Jinxiao didn't expect Chen Nan to call so soon and said, "Not busy."

Chen Nan smiled slightly: "Then you may be very busy in the next period of time."

Chen Nan's words made Sun Jinxiao stunned for a moment: "What do you mean?"

Chen Nan: "It's a pleasant cooperation. If you have time, please come directly."

"Our work needs to start, and you, there are many things to do."

Sun Jinxiao's eyes lit up immediately: "Director Chen, have you read my information?"

Chen Nan smiled slightly: "Early treatment is in line with my research philosophy."

"However, one more thing, the professional committee, I don't recognize them, because when I opened this research center, my research was rejected by them."

"So, I think we'll have a lot of shared ideas about working together."

"Ten minutes, go there right away!" Sun Jinxiao immediately hung up the phone, got up and said to Xu Maoxuan, "Let's go, follow me to the Crohn's Research Center!"

Xu Maoxuan's eyes widened immediately: "Chen...Chen Nan agreed?"

Sun Jinxiao smiled slightly: "From now on, I will be called Director Chen."

...

Not long!

Sun Jinxiao and Xu Maoxuan arrived at the Crohn's Disease Research Center of the Integrated Traditional Chinese and Western Medicine Ward.

Chen Nan summoned Zhao Jianyong and others to the office.

"Let me introduce to you, this one is Director Sun Jinxiao."

"He is also the second person in charge of our research work."

"I hope the cooperation will go smoothly in the days to come."

Sun Jinxiao nodded calmly, without any excitement or other emotions.

Instead, he asked a question indifferently: "Director Chen, wait a moment."

"I want to ask a question, what do you think about early treatment?"

Sun Jinxiao will decide whether to be the second person in charge only after getting a satisfactory answer.

Chen Nan glanced at Sun Jinxiao, feeling overjoyed.

To be honest, I am really lucky to meet such a talented person.

Chen Nan did not answer Sun Jinxiao's question directly, but said directly:

"I'm going to say one thing."

"Yesterday, we included a patient named Mitchell, who is a reporter from the British "Medical Forum" in China."

"He is also a patient with difficult Crohn's disease. He has been diagnosed with Crohn's disease for 12 years and has repeated symptoms. He induced the disease in the UK on March 3, and had belching and hiccups. However, because the disease was not serious, he did not It has attracted enough attention, and after arriving in China, the condition worsened..."

"There were repeated infections, high fever, pancytopenia, multiple lymph nodes, splenomegaly, abnormal coagulation function, and abnormal liver function."

"And then, in our department, several patients were in a similar situation to Mitchell. They all had symptoms such as belching and hiccups on March 3 this year, aggravated abdominal pain, and even a history of overseas travel..."

"then!"

"I asked these patients to do a genetic test."

"Obviously, I'm here and got an accurate message."

"These patients have congenital immunodeficiency and are due to a single gene mutation."

"They have mutations in the X-linked inhibitor of apoptosis protein (XIAP) gene on their X chromosome. This disease-causing gene mutation is the "culprit" of the disease. The XIAP gene mutation induces inflammation through the innate immune function defect of intestinal immune cells Sexual bowel disease."

"Therefore, XIAP-related adult single-gene mutant Crohn's disease is of great clinical significance, and it has significant significance for our development of Crohn's disease."

As soon as these words came out, the scene immediately fell silent.

Everyone stared at Chen Nan with wide eyes, their eyes full of disbelief.

"this……"

"Damn, there is progress so soon?!"

"This... is this too fast?"

Zhao Jianyong, Xue Zhongqing and others all felt like a dream at this time.

Only Sun Jinxiao!

At this moment, he was actually standing there, trembling all over!

Chen Nan kept silent, looking at Sun Jinxiao with a smile in his eyes.

After a while, he said slowly:

"Director Sun, do you still need me to continue?"

Sun Jinxiao shook his head excitedly: "No need!"

"enough!"

"enough!"

"Director Chen, thank you for letting me join your research group."

Xu Maoxuan was also stunned at this moment.

It never occurred to him that Chen Nan, who was misunderstood by everyone and even laughed at by countless people, would discover such an important clue.

Now it seems... who is the real big fool?

For a while, everyone was silent.

Xu Maoxuan couldn't help asking: "Director Chen... this... how did you discover these common points?"

Sun Jinxiao also looked at Chen Nan quickly, and also had this doubt.

"Yes, Director Chen, I have actually met some patients with similar onset times and similar symptoms."

"But how did you come up with this genetic problem?"

Chen Nan smiled: "This is Chinese medicine!"

"Traditional Chinese medicine's understanding of disease, in addition to innate endowment, pays attention to internal and external causes."

"After I noticed the patient's solar terms, I also observed several other patients."

"Coincidentally, I have discovered a very coincidental phenomenon, which is pulse diagnosis!"

"During the pulse diagnosis, the pulse is thin and weak, but it is floating, which is very interesting."

"This kind of floating pulse belongs to superficial syndrome, but the patient does not seem to be infected with external pathogens."

"So, I studied it according to the circle movement of traditional Chinese medicine and the thinking of five movements and six qi."

"The day of March 3rd was not a coincidence. The weather on that day was a bit manic and golden and easy to hurt the liver qi."

"Crohn's disease, it is reasonable to say that it is a blood disorder, but... it happens that there are frequent belching and hiccups."

"When these clues are connected together."

"Actually, the answer is not far away."

"It is nothing more than the lack of natural endowment of the patient, and the weakness of Qi and blood caused by Crohn's disease. The current five luck and six qi are restrained, which is easy to induce disease."

"The most important causes of Crohn's disease are infection and immunity, and the factors are genetic factors, environmental factors, and geographical factors."

"Isn't this the theory of five movements and six qi and the theory of innate endowment that my Chinese medicine practitioners call?"

"So, I thought about whether there was a genetic defect. This so-called genetic defect is a lack of congenital endowment."

"Sure enough, I found it!"

"The patient does have a genetic defect."

"This is good news."

At this moment, everyone on the scene was dumbfounded.

Zhao Jianyong stood where he was, and began to record what he said to Chen Nan frantically.

He also diagnoses and treats patients, and even does more by himself. Why didn't he think of these genetic defects?

That's the difference!

Xue Zhongqing shook his head helplessly.

And Sun Jinxiao and Xu Maoxuan looked at each other, and saw a trace of surprise in each other's eyes.

This theory really exceeded their expectations.

There is even a feeling of ignorance.

Sun Jinxiao never thought that Chinese medicine could be used in this way?

but!

He thought of something more.

"Director Chen, what do you mean... the significance of early treatment is to conduct genetic testing on patients with Crohn's disease in advance, and to provide timely intervention and treatment for patients with XIAP-related adult single gene mutations?"

"So... to achieve the purpose of early treatment?!"

Chen Nan nodded in satisfaction: "That's right!"

"Director Sun, this is your next job."

"In the past two days, I will treat existing patients and seek to find an effective preventive treatment plan."

"However, since it is a research center, you need to conduct controlled clinical trials, and conduct group studies on early treatment, biological agent treatment, symptomatic treatment, late treatment...etc."

"Looking at the specific clinical effects, I hope to find an effective treatment idea for this XIAP gene-deficient Crohn's disease."

Sun Jinxiao nodded quickly: "Director Chen, don't worry, we promise to complete the task!"

"Leave it to me, don't worry!"

Chen Nan nodded, and then looked at Zhao Jianyong: "Director Zhao, your job is to write a paper on the specific information of this XIAP-related adult single-gene mutant Crohn's disease patient, and I will publish it."

Zhao Jianyong nodded: "Okay!"

"Director Xue, you treat the patient with me and take notes. We need to find an effective treatment method for this patient."

Xue Zhongqing nodded quickly: "Got it!"

At this time, Chen Nan looked at Xu Maoxuan: "This is Director Xu, right now, you are cooperating with Director Sun's work, and I need you to be responsible for the follow-up matters."

After Xu Maoxuan heard Chen Nan's words, he was a little surprised.

He didn't expect...he had a chance too?

He quickly smiled gratefully: "Thank you, Director Chen."

...

Mitchell was lying on the hospital bed at this time, and his physical pain made him more mentally stressed.

And after being hospitalized for a day, Chen Nan didn't treat him. To be honest, Mitchell felt quite uncomfortable.

But he is also clear, how can the cursed people like him get better so easily?

Mitchell shook his head. Long-term immunosuppressants have made his immune system very bad, and it is easy to induce infection if he is not careful.

Why……

To be honest, Mitchell didn't have much expectation for this treatment.

At this time, there was a sound of opening the door.

Chen Nan led everyone into the ward.

"Hello, Doctor Chen."

Mitchell said hello anyway.

Chen Nan nodded: "Well, the treatment will start next."

"However, Mr. Mitchell, I have a request. I wonder if it is okay?"

Mitchell froze for a moment: "Doctor Chen, tell me."

Chen Nan said: "I hope you can publish this treatment on your "Medical Forum", can you?"

Mitchell's eyes widened suddenly: "Doctor Chen, this...you don't worry..."

"If the treatment doesn't work well, wouldn't that be good news for you?"

Chen Nan smiled: "I'm sure!"

This sentence is sure, so Mitchell is not confident.

If the Crohn's disease in the body could talk, it would definitely look puzzled: Who do you look down on?

At this time, Chen Nan continued:

"However, before that, I have something to tell you."

"Your situation, as well as several of our other patients, I will tell you in detail later, your Crohn's disease is more complicated."

"The culprit that causes you to have repeated infections, high fever, pancytopenia, multiple lymph nodes, splenomegaly, abnormal blood coagulation function, abnormal liver function and many other serious conditions is actually a genetic defect."

"You have a mutation in the X-linked inhibitor of apoptosis protein (XIAP) gene on your X chromosome, and mutations in the XIAP gene induce inflammatory bowel disease through a defect in the innate immune function of intestinal immune cells."

"That's why a more serious and special Crohn's reaction occurs."

"This is the inspection report!"

While speaking, Chen Nan handed the report to Mitchell.

After Mitchell heard it, he was dumbfounded.

"You... are you sure?"

Chen Nan nodded seriously: "I won't make this joke."

Mitchell was silent for a moment.

He didn't expect that his situation...was even more troublesome than ordinary patients.

"Are there many patients like me?"

Chen Nan shook his head: "XIAP-linked apoptosis inhibitory protein mutation is my latest discovery, and no large-scale research has been conducted yet."

"So... I need your help."

"Only by analyzing a large number of Crohn's patients can we have the opportunity to analyze this situation and take effective measures to treat it."

Mitchell sighed: "Good!"

"I will cooperate with you."

Chen Nan nodded: "Thank you..."

Mitchell shook his head helplessly: "Hey..."

"I am, really... a cursed person."

"Am I hopeless?"

Chen Nan shook his head: "I didn't say that? I said, I'm sure of the current situation."

"Don't worry, leave it to us."

Mitchell nodded: "Okay, thank you Director Chen."

At this time, Chen Nan put his hand on Mitchell's wrist again, and then observed his tongue.

After a while, Chen Nan turned to Xue Zhongqing and said:

"Yupingfeng powder is the main party."

"Add 5 grams of cloves, 10 grams of persimmon stalks, 5 grams of Gansong, 10 grams of light dried ginger, 10 grams of Codonopsis, 10 grams of fried Atractylodes macrocephala, 10 grams of fried white peony root, 6 grams of French pinellia, 10 grams of tangerine peel, turmeric 15 grams, 3 grams of ginger, 6 grams of licorice, 10 grams of jujube, 10 grams of inula, 6 grams of silkworm."

"One dose a day."

As Xue Zhongqing was writing, his pen stopped suddenly, and he looked at Chen Nan curiously:

"Director Chen, does this... the use of cloves and yujin together violate the principles of the Nineteen Fears? Doesn't it mean... that cloves should not be seen with Yujin?"

Chen Nan smiled slightly: "Eighteen Anti-Nineteen Fears? It doesn't matter!"

"On the contrary, the contraindications of drugs are not rote, one-size-fits-all, but based on the complex and changeable conditions of diseases and syndromes, specific analysis of specific problems, bold practice, careful exploration, inheritance and innovation."

"Here, it can be used."

"Cloves are pungent, warm in nature, can warm the middle and dispel cold, and are good at reducing adverse events. It is an important medicine for hiccups. Curcuma, pungent in taste, bitter and cold in nature, can relieve stagnation of qi, promote blood circulation and dissipate stasis, and has "qi medicine in blood" It is known as "hiccup and chronic illness that does not heal, which is consistent with prolonged illness and blood stasis, and the combination of cloves and turmeric can play a synergistic effect."

"Traditional Chinese medicine prescribes must not be copied mechanically, but must learn to integrate."

"In this disease, we should start with regulating the patient's qi movement. Patients often experience external evils, which stagnate inside, block the qi movement, and cause pain when they are blocked, resulting in cramping abdominal pain;

Disorder of movement of qi, dereliction of transportation and transformation, indiscriminate clearness and turbidity, resulting in vomiting and diarrhea; recurrent attacks, long-term illness deplete righteousness, resulting in deficiency of qi and blood, gradually forming asthenia, and the prognosis is not good. "

While speaking, Chen Nan looked at Sun Jinxiao:

"Director Sun, in fact, there are several cases of early treatment. Early detection of XIAP gene defects and prevention are one of them."

"After discovery, early treatment is also a kind of treatment."

"Early treatment should be carried out in stages and according to the situation."

"For patients with Crohn's disease, if you simply want to treat it in the early stage, it is actually quite difficult, but... Crohn's disease is a disease that persists and has complicated follow-up symptoms. It's all an early stage, and you can start from this angle!"

Hearing the sound, Sun Jinxiao widened his eyes, and after a moment of contemplation, nodded his head: "Taught!"

Chen Nan continued: "Director Xue, then perform enema No. 3 for enema treatment."

Later, Chen Nan looked at Mitchell: "Mr. Mitchell, you must remember that the symptoms change every day, we need you!"

"Also, about the XIAP gene mutation of the cascading apoptosis-inhibiting cells, you will publish it in five days, and I will publish the paper to cooperate with you then."

"At the same time, it happens that your situation will ease."

Mitchell looked at Chen Nan, wondering why this young man was so confident.

...

At this time, the first batch of model mice had been bred successfully.

Many institutions and hospitals have already made preparations and issued according to the application.

Qin Shiming can be said to be refreshed, they have such a good opportunity!

This time, in order to prevent favoritism and fraud, he personally came to supervise.

And this time...

Suddenly a phone call came, and the secretary Yang Ming hurried over.

He whispered to Qin Shiming, "Director Qin, it's Kong Xu, Mr. Kong!"

Qin Shiming quickly picked up the phone, and soon, he was slightly taken aback, but he still nodded and agreed.

"Okay, Mr. Kong, don't worry, this little matter won't affect you."

...

ps: I originally thought that this month would be on the 31st, and I planned to ask for a monthly pass on the 29th.

not first...

Oh my god, it's only the 28th, and it's already the 26th today, big guys.

It's the end of the month, and the baby asks for a monthly pass.

mwah!