Chapter 1748: Gene Optimization

Lu Jin came to his laboratory bench and took the alleles from the DNA fragments of Qin Yaoguang and Wen Shouyi for verification and comparison.

From a common sense, DNA identification of parent-child relationship, when the possibility of not being parent-child relationship is excluded, the accuracy rate can be 100%.

In other words, when it is determined that there is no blood relationship between two people, it is 100% accurate.

But to determine that there is a direct parent-child relationship between the two, the accuracy rate is only 99.99999%.

The nines after the decimal point can vary depending on how many intercepted alleles there are.

However, under normal circumstances, when the accuracy rate of determining that two people have a direct parent-child relationship reaches 99.99%, it can basically be determined that the two are direct parent-child relationship.

The DNA that Lu Jin tested for Qin Yaoguang and Wen Shouyi was the full sequence.

This is not only a sequencing that ordinary people cannot afford, even many people with millions of dollars may not be able to afford it. Of course, it is not a problem here in Lujin.

He tested the full sequence, and the intercepted alleles were as diverse as possible, so the parent-child relationship he tested had the highest accuracy even if it was not 100%.

Run electrophoresis before the test. Simply put, it is to let the DNA double helix structure "swim" under a certain voltage. DNA fragments with different functions "swim" at different speeds, so that different DNA fragments can be separated.

Then intercept the alleles, and then use the software to analyze and compare.

After Lu Jin completed a whole set of procedures, Gu Nianzhi watched with relish.

Although she couldn't understand those pictures and data at all.

In order to strive for accuracy, Lu Jin spent half an hour using software to analyze and compare the intercepted allelic fragments.

Finally, he let out a long sigh, "...they are really a mother-daughter relationship."

Gu Nianzhi: "..."

She was a little dazed by the result.

She was mentally prepared, but when this prediction was confirmed, she felt incredible.

"...Qin Yaoguang and Wen Shouyi?! Are they really the biological mother and daughter?!" Gu Nianzhi was extremely surprised, "It must be a surrogate? But why did she put Wen Shouyi in the Qin Orphanage? Later, Wen Dayou Adopted by a couple?!"

Lu Jin nodded, "Surrogacy must be the only explanation. But Qin Yaoguang can only ask Qin Yaoguang why he put Wen Shouyi in the orphanage."

"...But do you think she will tell the truth?" Gu Nianzhi said quietly, his eyes were bottomlessly dark.

Lu Jin said seriously: "She probably won't. But I think this is her privacy, do I have to ask?"

"Yes." Gu Nianzhi nodded cautiously, "This is related to the integrity of the court evidence supply chain. ——Dad, you know Qin Yaoguang better, can you reason why she did this?"

When Gu Nianzhi talked about legal terms, Lu Jin's eyes circled just like Gu Nianzhi heard high-energy physics terms.

He said in a daze: "Actually, I don't know Qin Yaoguang very well. But I have worked with her for so many years, and I basically know her attitude towards genetic research."

"What attitude?" Gu Nianzhi asked quickly.

"Gene research is one of her specialties. She uses her own egg cells to synthesize fertilized eggs and let other women surrogate them, just like catching a mouse from a cage."

"Which experimenter have you ever seen pour their feelings into a rat? Or treat the rat like a human?"

Gu Nianzhi curled her lips and muttered, "I'm also a guinea pig, but Qin Yaoguang uses me for experiments, why not throw me into an orphanage. Why doesn't she use Wen Shouyi for experiments?"

Lu Jin's heart ached, and he didn't know how to comfort her.

In desperation, he subconsciously said, "...Maybe Wen Shouyi is the product of a failed experiment, so she was not used for the experiment."

Gu Nianzhi: "..."

Although I was not comforted, my mood miraculously improved, what a fat thing...

Gu Nianzhi still had a straight face, and said solemnly: "It seems that I am still useful.

"

Lu Jin rubbed his hands together in embarrassment, begging for mercy, "...read it, Dad knew it was wrong..."

Gu Nianzhi felt embarrassed, stepped forward to hold Lu Jin's hand, pulled him to the sofa and sat down, and said, "Dad, I was just joking. But..."

Her eyes rolled around, "You mean, Qin Yaoguang started doing research on embryonic genes long before I was born?"

This question can be answered.

Lu Jin said very academically: "I don't have concrete evidence, but since Wen Shouyi was born in this way, Qin Yaoguang must have done research on it."

"At that time, she didn't ask me for advice, so I didn't know that she was already doing experiments in this area."

In other words, six years before Gu Nianzhi was born, Lu Jin knew nothing about Qin Yaoguang's secret experiment.

Gu Nianzhi nodded, and continued to ask curiously: "But why did she use her own egg cells and Wen Dayou's sperm as fertilized eggs to conceive embryos? I thought she would use other people's egg cells for research."

Lu Jin smiled, and said casually: "If she has already had such an experiment, then she is definitely not the first to do this experiment, nor will she be the last."

"What do you mean?" Gu Nianzhi's eyes suddenly lit up, "Could it be that she has done many research experiments in this area, even using other people's egg cells?"

"From the perspective of scientific experiments, that is certain."

Lu Jin patiently explained to her: "It takes a long time to do this kind of human embryo experiment. Generally, it takes seven months at the fastest from fertilization to the birth of the fetus, that is, if premature babies are included."

"Normally, it would take nine months. In addition to the preparations before and after, the process of screening men and women for pregnancy will take a year."

"When an experiment takes a year from preparation to results, the person doing the experiment will never do one experiment at a time, do you understand what I mean?"

Gu Nianzhi carefully digested Lu Jin's words in his mind, and after a while, he said thoughtfully: "You mean, doing this kind of experiment is no different from doing other biological experiments, and a large number of experiments are required. , in order to filter out effective results.”

"She will prepare a lot of fertilized eggs like this, transplant them into the pregnant mother's stomach at the same time, and then observe the results."

Lu Jin nodded heavily, "That's the reason. The failure rate of biological genetic experiments is actually quite high. Therefore, she needs to accumulate quantities to achieve qualitative changes from quantitative changes."

"And to do so many experiments, Qin Yaoguang definitely can't just use her own egg cells." Lu Jin popularized the common sense of egg cells to Gu Nianzhi in a scientific tone.

"The females of all mammals are born with immature eggs in their ovaries."

"The number of egg cells in female animals is fixed at birth, and will not increase, but will gradually decrease."

"So it is impossible for Qin Yaoguang to use only her own egg cells for this kind of large-scale experiment. She must have used other people's egg cells."

Gu Nianzhi fully understood, covered her mouth with her hands, and gasped: "...Oh my God! How many embryo experiments did Qin Yaoguang do?! How many Wen Shouyi and Gu Nianzhi were born by her using this method?! "

Lu Jin smiled wryly, "Nian Zhi, do you really think this kind of experiment is easy to succeed?"

"Do you think it's grafting and raising seedlings?"

Gu Nianzhi: "..."

She really thinks so!

"Could it be...more difficult?" Gu Nianzhi's thick black and slender eyelashes fluttered, and his big eyes were full of curiosity.

"It's not more difficult, it's very difficult." Lu Jin didn't know how to explain to Gu Nianzhi, "I checked Wen Shouyi's full DNA sequence just now, and I can see that Qin Yaoguang tried to genetically edit her, but failed. "

Gu Nianzhi frowned, "That is to say, before she gave birth to me, she began to edit the embryos, or was it for... He Shao's disease?"

"Whether she let Wen Shouyi give birth to He Chuchu's illness, I don't know, but it might be the embryonic form of her idea. From then on, she began to experiment with this method."

"But you have to know that human genes are very complicated and huge. Decades ago, our understanding of genes was not as comprehensive as it is now, and the instruments and technical means were not as advanced as they are now."

"In embryo experiments under that circumstance, there are very few fertilized eggs that can successfully implant. It can be said that out of a thousand gene-edited fertilized eggs, only one can successfully implant and conceive the mother."

"And after these implanted fertilized eggs develop into embryos, one out of a hundred can be born smoothly."

Gu Nianzhi was very puzzled, "You mean, those embryos that are pregnant will be aborted?"

"Of course. And the chance of miscarriage is very high." Lu Jin sighed, "Because these embryos are genetically edited, many of them have genetic defects."

"The human body has the function of self-selection. Embryos with genetic defects, known as congenital defects, will be aborted in a natural state, unless you use unconventional means to preserve the fetus."

"For a scientific experiment, we don't give birth to embryos with birth defects, you know what I mean? - Very, very few children are actually successfully born and survived after gene editing. I doubt it, Among Qin Yaoguang's experiments, Wen Shouyi was probably the only embryo that was born and survived."

Gu Nianzhi nodded slowly, she understood a little, but she had a new question.

"...You said that the gene-edited embryos all have congenital genetic defects, so is it the same for me...and Wen Shouyi?"

Lu Jin shook his head first, then nodded, and said, "You don't, Wen Shouyi does."

Gu Nianzhi: "..."

"Why didn't I?" Gu Nianzhi was very suspicious, "Dad, don't say such things just to comfort me."

"I didn't comfort you. You are questioning my professional ability!" Lu Jin's eyes widened, "...you are the gene editor I personally did!"

"My approach is completely different from that of Qin Yaoguang. She disrupts the order of the original gene fragments and only cultivates the defective genes of He Zhichu."

"On the basis of your original genes, I exclude those non-human virus genes, and then use your own genes to expand and express them and add them in."

"As a result of this, your genes have not been changed, but have been optimized to the greatest extent on the original basis."

Lu Jin couldn't help feeling complacent: "Facts have proved that I succeeded. You have the first set of perfect genes in human history! ——and without changing your original genes!"

Gu Nianzhi: "x-on:_x-on:".

She started to have mosquito-repellent eyes again.

She knew every word Lu Jin said, but she couldn't understand it together.

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This is the first update today: Chapter 1748 "Gene Optimization".

Two updates today.

Remind everyone of monthly tickets and recommended tickets.

Today is Monday, special recommended tickets!

The second update at eight o'clock in the evening.

Hey guys, little angels~~~

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