Chapter 203 Doesn’t It Look Simple?

When he thought of this, Dean Song quickly explained to Lin Shengli: "You must not misunderstand that Shengli!"

"I will ask someone to take you to the laboratory in a moment. While you are preparing the medicine, no one will be allowed to disturb you, including me and no one else will go in."

Hearing that Aunt Song seemed to have misunderstood something, Lin Shengli smiled and said, "Aunt Song, I think you have misunderstood."

"As I said just now, I fully trust you."

"Besides, I do need your help."

"One more thing, you might as well listen to my two conditions. It's not too late for you to make a decision."

Hearing Lin Shengli's words, Dean Song looked slightly nervous, then calmed down and said, "Shengli, if there is any difficulty or what the conditions are, you might as well just stop talking about it."

"It's my fault that Auntie didn't think carefully enough. Otherwise, it's better to do it the way Auntie just said."

In fact, now, Dean Song no longer cares about what conditions Lin Shengli will propose next.

Whenever there was any misunderstanding or embarrassment to Lin Shengli, she would never ask her students or herself to attack Lin Shengli.

They say a son-in-law is half a son.

Dean Song, who had long regarded his niece as his biological daughter, would also regard Lin Shengli, his future son-in-law, as half a son.

On this side are his students and on the other side are his prospective sons-in-law.

She can still distinguish between the distant and the distant, what is light and what is important.

Hearing Dean Song's words, Lin Shengli smiled and said, "Aunt Song, there's nothing to be embarrassed about."

"My two conditions are, first, to keep everything I saw and heard today confidential."

"Second, when we are preparing drugs in the laboratory, we are not allowed to ask questions or take notes."

Lin Shengli's request was really not that he judged a gentleman with a villain's heart and had to think the worst of people.

As the saying goes, you must not have the intention to harm others, and you must not have the intention to guard against others.

Although the formulas of these two medicines were only brought by Lin Shenglibai through prostitution, in this era, if he takes them out, they are his.

After Lin Shengli was able to get it, he donated it to the country for free, but he did not allow anyone to prostitute him for free, or even take these valuable drug formulas to seek refuge with external forces!

As long as you are not allowed to ask questions or record during the process of preparing medicines, no matter what kind of professional you are, Lin Shengli doesn't believe that there is anyone like him, who is also a master, who can understand all the preparation steps and everything. Remember all the parameters exactly!

You must know that when conducting scientific research experiments, the difference can be described as a hair's breadth and a thousand miles away. As long as any step is wrong, the final result will be completely different and completely different!

After hearing Lin Shengli's request, Dean Song was relieved, but he still said again: "Shengli, Auntie agrees to both of the two conditions you mentioned."

"But if you are really in trouble, don't be embarrassed, and don't worry about Auntie."

Lin Shengli shook his head and said with a smile, "It's okay, Aunt Song. I really have nothing to embarrass you here, as long as you agree to my two conditions."

"Besides, I really need someone to help me."

"You also know that I am also busy with work here and cannot delay too long just to prepare medicines."

"With help, it can be done quickly, right?"

After hearing what Lin Shengli said, Dean Song nodded and stopped worrying about anything.

Then, Dean Song stood up and said, "Let's go, Shengli, I'll take you to the laboratory."

"Okay, Aunt Song."

On the way to the laboratory, Dean Song called Lu Xusheng to his side and whispered a few words.

Lin Shengli followed behind him and vaguely heard that Dean Song was probably telling Lu Xusheng some rules to abide by.

Siqiucheng Medical University, a laboratory.

This is indeed one of the best medical universities in the country. The instruments and equipment in this laboratory are really good and complete.

Many instruments and equipment were well maintained. Lin Shengli scanned them with plain glasses and found that the accuracy of many instruments was very good and they were all in the best condition!

This way, it would save him the trouble of adjusting and calibrating these instruments and equipment.

Lin Shengli took out a pen and paper, wrote out the reagents and related materials that needed to be used, and handed them to Dean Song.

After that, he began to prepare the first drug he wanted to produce, amoxicillin.

Amoxicillin, also translated as amoxicillin or amoxicillin, whose real name is ampicillin, is a commonly used oral broad-spectrum beta-lactam antibiotic. It was developed by John Bull's Beecham Company in 1968 and It was launched in 1972 under the trade name AMOXIL.

Because of its broad antibacterial spectrum and can be used to treat a variety of common infectious diseases, amoxicillin is listed on the World Health Organization's Model List of Essential Medicines as one of the essential drugs in the medical system.

And preparing amoxicillin is actually not difficult at all!

Just need: Prepare reagents: 1. Acetonitrile; 2. Potassium dihydrogen phosphate solution (0.05mol/L); 3. Potassium hydroxide solution (2mol/L)

Required instruments and equipment: 1. Instrument; 1.1 High performance liquid chromatograph; 1.2 Chromatographic column, octadecylsilane bonded silica gel is used as filler, the number of theoretical plates should not be less than 2000 based on the amoxicillin peak. 1.3 Ultraviolet Absorption detector

2. Chromatographic conditions: 2.1 Mobile phase: 0.05mol/L potassium dihydrogen phosphate solution (use 2mol/L potassium hydroxide solution to adjust the pH to 5.0) acetonitrile = 97.5 2.5; 2.2 Detection wavelength: 254nm; 2.3 Column temperature: room temperature; 2.4 Flow rate: 1mL/min

Sample preparation: 1. Preparation of reference substance solution: Precisely weigh about 25 mg of amoxicillin reference substance, place it in a 50 mL volumetric flask, add mobile phase to dissolve and quantitatively dilute to the mark, shake well, and this is the reference substance solution.

2. Preparation of the test solution: Precisely weigh about 25 mg of the test product, place it in a 50 mL volumetric flask, add mobile phase to dissolve and quantitatively dilute to the mark, shake well, and the test solution is obtained.

Subsequent steps: Precisely draw 20 mL each of the reference solution and the test solution, inject them into the high-performance liquid chromatograph, use a UV absorption detector to measure the peak area of ​​amoxicillin (C16H19N3O5S) at a wavelength of 254 nm, and calculate its content. .

With these steps, it looks very simple!

This is a simple method that Lin Shengli transferred from a book written in another time and space in the 21st century.

Back then, it took John Bull five or six years from drug development to launch.

Now, under the guidance of Lin Shengli’s strong theoretical knowledge and the help of Dean Song and classmate Lu’s strong practical abilities.

In one morning, I easily produced hundreds of pieces of finished amoxicillin.

At noon, in the cafeteria of the Medical University, Lin Shengli also enjoyed a meal from the university cafeteria.

Well, the overall feeling is okay, but compared to the small stove that Shazhu made for him in the canteen when he was in the steel rolling mill, it is still a bit far behind.

In the afternoon, Lin Shengli followed the same pattern and produced hundreds of tablets of another medicine.

When Lin Shengli was leaving the Medical University in the evening, Dean Song asked Lin Shengli for 100 tablets of each medicine, saying that he wanted to take them for testing and clinical trials.

Lin Shengli agreed to Dean Song's request without even thinking about it.

After declining the kindness of Dean Song and classmate Lu to have him have dinner, Lin Shengli thanked Dean Song, borrowed the laboratory and helped prepare medicines, and left the medical university.